Linzess and Pulmozyme drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Linzess (linaclotide) and Pulmozyme (dornase alfa). Common drug interactions include dysarthria among females and infective pulmonary exacerbation of cystic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Linzess and Pulmozyme. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

What is Pulmozyme?

Pulmozyme has active ingredients of dornase alfa. It is often used in cystic fibrosis. eHealthMe is studying from 20,012 Pulmozyme users. Check the latest studies of Pulmozyme.

On Jul, 20, 2026

95 people who take Linzess and Pulmozyme together, and have interactions are studied.

Linzess and Pulmozyme drug interactions.

What are the common drug interactions of Linzess and Pulmozyme, by gender? *:

female:

Dysarthria (speech disorder)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Flatulence (flatus expelled through the anus)
Gastric disorder (disease of stomach)
Human chorionic gonadotropin decreased
Hypertrichosis (hair growth on the body in an amount considered abnormal)
Hypoaesthesia (reduced sense of touch or sensation)
Insulin resistance
Irritability
Lethargy (tiredness)

male:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Abdominal pain upper
Carbon dioxide increased
Cardiac disorder
Diarrhoea
Dyspepsia (indigestion)
Electrolyte imbalance
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Linzess and Pulmozyme, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abortion spontaneous (naturally occurring miscarriage)
Human chorionic gonadotropin decreased
Lung disorder (lung disease)
Pneumonia
Pyrexia (fever)
Surgery

20-29:

Fatigue (feeling of tiredness)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Hospitalisation
Abdominal discomfort
Abdominal pain upper
Anxiety
Depression
Headache (pain in head)
Insomnia (sleeplessness)
Oropharyngeal pain

30-39:

Depression
Abdominal discomfort
Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Delusion (a false belief or opinion)
Disturbance in attention
Fatigue (feeling of tiredness)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Lung disorder (lung disease)
Muscle fatigue (a condition in which muscles cannot exert their normal force)

40-49:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Influenza
Abdominal pain lower
Cough
Gastric disorder (disease of stomach)
Hyperkalaemia (damage to or disease of the kidney)
Lung disorder (lung disease)
Lung transplant
Oedema peripheral (superficial swelling)

50-59:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Carbon dioxide increased
Hospitalisation

60+:

Dehydration (dryness resulting from the removal of water)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Infection
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

What are the existing conditions these people have? *

Cystic Fibrosis Lung (fibrosis with cyst in the lung): 6 people, 6.32%

* Approximation only. Some reports may have incomplete information.

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