Lipoic acid and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lipoic acid (alpha - lipoic acid) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include injection site pruritus among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Lipoic acid and Hydrocodone. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Lipoic acid?

Lipoic acid has active ingredients of alpha - lipoic acid. It is often used in peripheral neuropathy. eHealthMe is studying from 5,920 Lipoic acid users. Check the latest studies of Lipoic acid.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 26, 2026

28 people who take Lipoic acid and Hydrocodone together, and have interactions are studied.

Lipoic acid and Hydrocodone drug interactions.

What are the common drug interactions of Lipoic Acid and Hydrocodone, by gender? *:

female:

Injection site pruritus (severe itching at injection site)
Nasopharyngitis (inflammation of the nasopharynx)
Neuralgia (pain in one or more nerves)
Oropharyngeal pain
Post procedural cellulitis (post procedural bacterial infection of the skin and soft tissues)
Rosacea (a skin condition that causes facial redness)
Drug ineffective
Abdominal discomfort
Cardiac disorder
Chronic kidney disease

male:

Pain
Weight decreased
Prostate cancer
Pruritus (severe itching of the skin)
Pyrexia (fever)
Sinus congestion (blockage of sinus)
Urticaria (rash of round, red welts on the skin that itch intensely)
Urinary retention (the inability to completely or partially empty the bladder)
Urinary tract disorder
Urinary tract infection

What are the common drug interactions of Lipoic Acid and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Breast enlargement
Chest pain
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glycosylated haemoglobin increased
Ingrowing nail
Neuropathy peripheral (surface nerve damage)

60+:

Drug ineffective
Hypotension (abnormally low blood pressure)
Influenza
Injection site pruritus (severe itching at injection site)
Nasopharyngitis (inflammation of the nasopharynx)
Neuralgia (pain in one or more nerves)
Oropharyngeal pain
Post procedural cellulitis (post procedural bacterial infection of the skin and soft tissues)
Rosacea (a skin condition that causes facial redness)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 13 people, 46.43%
Asthma: 6 people, 21.43%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 14.29%
Multiple Myeloma (cancer of the plasma cells): 4 people, 14.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 14.29%
Stress And Anxiety: 3 people, 10.71%
Prostate Cancer: 2 people, 7.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 7.14%
Depression: 2 people, 7.14%
Burning Mouth Syndrome (pain in the mouth and burning sensation on tongue): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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