Lithium carbonate and Methylfolate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lithium carbonate (lithium carbonate) and Methylfolate (folic acid). Common drug interactions include insomnia among females and heart rate increased among males.

The phase IV clinical study analyzes what interactions people have when they take Lithium carbonate and Methylfolate. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Lithium carbonate?

Lithium carbonate has active ingredients of lithium carbonate. It is often used in bipolar disorder. eHealthMe is studying from 25,652 Lithium carbonate users. Check the latest studies of Lithium carbonate.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,018 Methylfolate users. Check the latest studies of Methylfolate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15 people who take Lithium carbonate and Methylfolate together, and have interactions are studied.

Lithium carbonate and Methylfolate drug interactions.

What are the common drug interactions of Lithium Carbonate and Methylfolate, by gender? *:

female:

Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)
Memory impairment
Neurotransmitter level altered
Sedation
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Suicidal ideation
Eyelid ptosis (falling of the upper or lower eyelid)

male:

Heart rate increased
Osteoporosis (bones weak and more likely to break)

What are the common drug interactions of Lithium Carbonate and Methylfolate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Haemorrhage (bleeding)
Herpes zoster
Muscle spasms (muscle contraction)
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Uterine pain

30-39:

Agitation (state of anxiety or nervous excitement)
Cerebral disorder (brain disease)
Daydreaming
Drug dependence
Eyelid ptosis (falling of the upper or lower eyelid)
Feeling hot
General physical health deterioration (weak health status)
Headache (pain in head)
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)

40-49:

Daydreaming
Drug dependence
Drug ineffective
Feeling hot
General physical health deterioration (weak health status)
Headache (pain in head)
Heart rate increased
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)
Memory impairment

50-59:

Tremor (trembling or shaking movements in one or more parts of your body)
Osteoporosis (bones weak and more likely to break)

60+:

Glomerular filtration rate decreased
Herpes zoster
Ill-defined disorder
Injection site pruritus (severe itching at injection site)
Pain
Rash

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 40.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 26.67%
Depression: 4 people, 26.67%
Affective Disorder (mental disorder): 3 people, 20.00%
Injury: 3 people, 20.00%
Diabetes: 3 people, 20.00%
Feeling Abnormal: 3 people, 20.00%
High Blood Cholesterol: 3 people, 20.00%
Sleep Disorder: 3 people, 20.00%
Insomnia (sleeplessness): 3 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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