Locoid and Cyclophosphamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Locoid (hydrocortisone butyrate) and Cyclophosphamide (cyclophosphamide). Common drug interactions include nodular regenerative hyperplasia among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Locoid and Cyclophosphamide. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Locoid?

Locoid has active ingredients of hydrocortisone butyrate. eHealthMe is studying from 1,996 Locoid users. Check the latest studies of Locoid.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

24 people who take Locoid and Cyclophosphamide together, and have interactions are studied.

Locoid and Cyclophosphamide drug interactions.

What are the common drug interactions of Locoid and Cyclophosphamide, by gender? *:

female:

Nodular regenerative hyperplasia (regeneration of a skin condition characterized by crops of small, tender, erythematous nodules on the legs)
C-reactive protein increased
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Urinary tract infection
Arrhythmia (irregular heartbeat)
Atopy (a genetic disposition to develop an allergic reaction)

male:

Cellulitis (infection under the skin)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Septic shock (shock due to blood infection)
Transplant rejection (a transplant material is not worked)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

What are the common drug interactions of Locoid and Cyclophosphamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nodular regenerative hyperplasia (regeneration of a skin condition characterized by crops of small, tender, erythematous nodules on the legs)
Atopy (a genetic disposition to develop an allergic reaction)
Erythema multiforme (a type of hypersensitivity reaction)
Skin infection
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

50-59:

Acute lymphocytic leukaemia (cancer of the white blood cells)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Platelet count decreased
Rash
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Arrhythmia (irregular heartbeat)

60+:

C-reactive protein increased
Cellulitis (infection under the skin)
Urinary tract infection
Escherichia sepsis (bacterial infection by escherichia coli)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Sepsis (a severe blood infection that can lead to organ failure and death)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Urinary tract infection bacterial
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Rashes (redness): 8 people, 33.33%
Nausea (feeling of having an urge to vomit): 8 people, 33.33%
Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 7 people, 29.17%
Constipation: 7 people, 29.17%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 6 people, 25.00%
Itching: 6 people, 25.00%
Abdominal Pain Upper: 4 people, 16.67%
Upper Respiratory Tract Infection: 4 people, 16.67%
Anaemia (lack of blood): 4 people, 16.67%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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