Lokelma and Glipizide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lokelma (sodium zirconium cyclosilicate) and Glipizide (glipizide). Common drug interactions include mental status changes among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Lokelma and Glipizide. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Lokelma?

Lokelma has active ingredients of sodium zirconium cyclosilicate. eHealthMe is studying from 1,678 Lokelma users. Check the latest studies of Lokelma.

What is Glipizide?

Glipizide has active ingredients of glipizide. It is often used in diabetes. eHealthMe is studying from 64,852 Glipizide users. Check the latest studies of Glipizide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

23 people who take Lokelma and Glipizide together, and have interactions are studied.

Lokelma and Glipizide drug interactions.

What are the common drug interactions of Lokelma and Glipizide, by gender? *:

female:

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Cardiac failure congestive
Constipation
Death
Hospitalisation
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)

male:

Constipation
Diarrhoea
Abdominal discomfort
Blood glucose increased
Chest pain
Chronic kidney disease
Dizziness
Drug hypersensitivity
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Lokelma and Glipizide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Constipation
Hospitalisation
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Blood glucose increased
Cardiac failure congestive
Chest pain
Chronic kidney disease
Dizziness
Drug hypersensitivity
Flushing (the warm, red condition of human skin)

What are the existing conditions these people have? *

Hyperkalemia (damage to or disease of the kidney): 8 people, 34.78%
Prostate Cancer: 3 people, 13.04%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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