Lomotil and Corgard drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride) and Corgard (nadolol). Common drug interactions include small intestinal obstruction among females and bone density decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Lomotil and Corgard. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Corgard?

Corgard has active ingredients of nadolol. It is often used in high blood pressure. eHealthMe is studying from 3,342 Corgard users. Check the latest studies of Corgard.

On Jul, 20, 2026

20 people who take Lomotil and Corgard together, and have interactions are studied.

What are the common drug interactions of Lomotil and Corgard, by gender? *:

female:

Small intestinal obstruction (blockage in small intestine)
Staphylococcal infection (an infection with staphylococcus bacteria)
Stomatitis (inflammation of mucous membrane of mouth)
Syncope (loss of consciousness with an inability to maintain postural tone)
Weight decreased
Foot fracture
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain

male:

Bone density decreased
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Nephropathy toxic (damage to kidney due to toxins)
Pain
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Emotional distress
Exercise tolerance decreased
Hyperkalaemia (damage to or disease of the kidney)

What are the common drug interactions of Lomotil and Corgard, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Bone density decreased
Chronic kidney disease
Emotional distress
Exercise tolerance decreased
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)

50-59:

Foot fracture
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Pain in extremity
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Abdominal pain
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dehydration (dryness resulting from the removal of water)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperglycaemia (high blood sugar)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Renal failure acute (rapid kidney dysfunction)
Agitation (state of anxiety or nervous excitement)
Anal haemorrhage

What are the existing conditions these people have? *

Pain: 6 people, 30.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 25.00%
Headache (pain in head): 5 people, 25.00%
Joint Pain: 3 people, 15.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 15.00%
Tension Headache: 3 people, 15.00%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 10.00%
Cardiac Failure Congestive: 2 people, 10.00%
Chest Pain: 2 people, 10.00%
Thyroid Diseases: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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