Lomotil and Cotrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride) and Cotrim (sulfamethoxazole; trimethoprim). Common drug interactions include migraine among females and aortic stenosis among males.

The phase IV clinical study analyzes what interactions people have when they take Lomotil and Cotrim. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

On Jul, 06, 2026

14 people who take Lomotil and Cotrim together, and have interactions are studied.

What are the common drug interactions of Lomotil and Cotrim, by gender? *:

female:

Migraine (headache)
Mitral valve incompetence (inefficient heart valve)
Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac failure
Hypertension (high blood pressure)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Neuropathy peripheral (surface nerve damage)
Oedema (fluid collection in tissue)

male:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve incompetence
Constipation
Cough
Depression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dizziness
Dry skin
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Lomotil and Cotrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Migraine (headache)
Mitral valve incompetence (inefficient heart valve)
Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiac failure
Hypertension (high blood pressure)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Neuropathy peripheral (surface nerve damage)
Oedema (fluid collection in tissue)

60+:

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve incompetence
Constipation
Cough
Depression
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dizziness
Dry skin
Dysgeusia (disorder of the sense of taste)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 92.86%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 12 people, 85.71%
Fluid Retention (an abnormal accumulation of fluid in the blood): 12 people, 85.71%
Multiple Myeloma (cancer of the plasma cells): 12 people, 85.71%
Mood Swings (an extreme or rapid change in mood): 12 people, 85.71%
High Blood Cholesterol: 12 people, 85.71%
Joint Pain: 12 people, 85.71%
Blood Triglycerides Decreased: 6 people, 42.86%
Seasonal Allergy (allergic condition due to certain season): 6 people, 42.86%
Hiv Infection: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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