Lomotil and Esbriet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride) and Esbriet (pirfenidone). Common drug interactions include drug intolerance among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Lomotil and Esbriet. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Esbriet?

Esbriet has active ingredients of pirfenidone. eHealthMe is studying from 39,858 Esbriet users. Check the latest studies of Esbriet.

On Jul, 25, 2026

35 people who take Lomotil and Esbriet together, and have interactions are studied.

What are the common drug interactions of Lomotil and Esbriet, by gender? *:

female:

Drug intolerance (drug sensitivity)
Hypoxia (low oxygen in tissues)
Infection
Pulmonary oedema (fluid accumulation in the lungs)
Weight decreased
Dizziness
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Rash
Abdominal discomfort

male:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Dyspnoea (difficult or laboured respiration)
Extraocular muscle paresis (nerve paralysis outside of eye tissue)
Gastritis (inflammation of stomach)
Headache (pain in head)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Intervertebral disc protrusion (spinal disc protrusion)

What are the common drug interactions of Lomotil and Esbriet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal discomfort
Anxiety
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Dizziness
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Nervousness

60+:

Dizziness
Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Back pain
Balance disorder
Dehydration (dryness resulting from the removal of water)
Extraocular muscle paresis (nerve paralysis outside of eye tissue)
Gastritis (inflammation of stomach)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

Idiopathic Pulmonary Fibrosis (chronic lung disease): 26 people, 74.29%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 8.57%
Chronic Respiratory Failure: 3 people, 8.57%
Stress And Anxiety: 2 people, 5.71%
Pain: 2 people, 5.71%
Nausea (feeling of having an urge to vomit): 2 people, 5.71%
Muscle Spasms (muscle contraction): 2 people, 5.71%
Insomnia (sleeplessness): 2 people, 5.71%
Hypersensitivity: 2 people, 5.71%
High Blood Cholesterol: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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