Lomotil and Flolan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride) and Flolan (epoprostenol sodium). Common drug interactions include hypoxia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lomotil and Flolan. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Flolan?

Flolan has active ingredients of epoprostenol sodium. eHealthMe is studying from 10,067 Flolan users. Check the latest studies of Flolan.

On Jul, 31, 2026

22 people who take Lomotil and Flolan together, and have interactions are studied.

What are the common drug interactions of Lomotil and Flolan, by gender? *:

female:

Hypoxia (low oxygen in tissues)
Pulmonary haemorrhage (acute bleeding from the lung)
Cardiac failure
Catheter related complication
Circulatory collapse
Death
Dyspnoea (difficult or laboured respiration)
Thrombocytopenia (decrease of platelets in blood)
Heparin-induced thrombocytopenia
Bradycardia (abnormally slow heart action)

male:

Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Viral infection
Blood culture positive
Central line infection (infection by central line in icu)
Fatigue (feeling of tiredness)
Haemorrhage (bleeding)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

What are the common drug interactions of Lomotil and Flolan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death
Impaired gastric emptying
Nausea (feeling of having an urge to vomit)
Vomiting
Catheter site pruritus (itching at the site)
Catheter site related reaction
Hospitalisation
Infusion site pruritus (severe itching at infusion site)
Infusion site vesicles (fluid- or air-filled cavity or sac at infusion site)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

40-49:

Dyspnoea (difficult or laboured respiration)
Hypoxia (low oxygen in tissues)
Pulmonary haemorrhage (acute bleeding from the lung)
Cardiac failure
Circulatory collapse
Thrombocytopenia (decrease of platelets in blood)
Heparin-induced thrombocytopenia
Bradycardia (abnormally slow heart action)
Cardiac failure high output
Arthralgia (joint pain)

50-59:

Haemorrhage (bleeding)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)

60+:

Catheter related complication
Death
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pulmonary hypertension secondary (increase in blood pressure in the lung artery)
Oedema (fluid collection in tissue)
Anaemia (lack of blood)
Blood culture positive
Central line infection (infection by central line in icu)
Device occlusion
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 45.45%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 8 people, 36.36%

* Approximation only. Some reports may have incomplete information.

Do you take Lomotil and Flolan?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously