Lomotil and Thalidomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride) and Thalidomide (thalidomide). Common drug interactions include lymphopenia among females and bone disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Lomotil and Thalidomide. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Thalidomide?

Thalidomide has active ingredients of thalidomide. eHealthMe is studying from 16,473 Thalidomide users. Check the latest studies of Thalidomide.

On Jul, 24, 2026

57 people who take Lomotil and Thalidomide together, and have interactions are studied.

Lomotil and Thalidomide drug interactions.

What are the common drug interactions of Lomotil and Thalidomide, by gender? *:

female:

Lymphopenia (an abnormally low level of lymphocytes in the blood)
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Weight decreased
Cushingoid (obesity and weakening of the muscles)
Gastric haemorrhage (bleeding stomach)
Haemoglobin decreased
Leukopenia (less number of white blood cells in blood)

male:

Bone disorder
Depression
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Hypoaesthesia (reduced sense of touch or sensation)
Dizziness
Multiple myeloma (cancer of the plasma cells)
Chest pain
Arthralgia (joint pain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Spinal osteoarthritis (joint cartilage loss in spine)

What are the common drug interactions of Lomotil and Thalidomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Renal failure (kidney dysfunction)
Back pain
Bone disorder
Compression fracture (fracture due to pressure caused by injury)
Fatigue (feeling of tiredness)
Gait disturbance
Osteonecrosis of jaw (death of bone of jaw)
Tooth extraction
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Pneumonia

60+:

Bone disorder
Depression
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hypoaesthesia (reduced sense of touch or sensation)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Syncope (loss of consciousness with an inability to maintain postural tone)
Toothache (tooth pain)
Cough
Osteonecrosis of jaw (death of bone of jaw)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 48 people, 84.21%
High Blood Pressure: 26 people, 45.61%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 25 people, 43.86%
Mood Swings (an extreme or rapid change in mood): 25 people, 43.86%
Joint Pain: 25 people, 43.86%
High Blood Cholesterol: 25 people, 43.86%
Fluid Retention (an abnormal accumulation of fluid in the blood): 25 people, 43.86%
Seasonal Allergy (allergic condition due to certain season): 18 people, 31.58%
Blood Triglycerides Decreased: 18 people, 31.58%

* Approximation only. Some reports may have incomplete information.

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