Lomotil and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lomotil (atropine sulfate; diphenoxylate hydrochloride) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include fatigue among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Lomotil and Tylenol w/ codeine. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Lomotil?

Lomotil has active ingredients of atropine sulfate; diphenoxylate hydrochloride. It is often used in diarrhea. eHealthMe is studying from 19,184 Lomotil users. Check the latest studies of Lomotil.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

On Jul, 24, 2026

75 people who take Lomotil and Tylenol w/ codeine together, and have interactions are studied.

Lomotil and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Lomotil and Tylenol W/ Codeine, by gender? *:

female:

Fatigue (feeling of tiredness)
Gastric ulcer (stomach ulcer)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Grandiosity (an unrealistic sense of superiority)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)
Homicidal ideation (thoughts about human killing another human)
Hospitalisation
Injection site erythema (redness at injection site)
Joint swelling

male:

Abdominal pain upper
Abdominal pain
Pancreatitis (inflammation of pancreas)
Pyrexia (fever)
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood alkaline phosphatase nos increased
Blood bilirubin increased
Blood carbon dioxide decreased
Blood creatinine increased

What are the common drug interactions of Lomotil and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Abdominal adhesions (inflammation of abdomen)
Abdominal pain
Abdominal pain upper
Anaemia (lack of blood)
Blood creatinine increased
Blood in stool
Breathing kussmaul type
Cardiomegaly (increased size of heart than normal)
Coma (state of unconsciousness lasting more than six hours)

40-49:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Bedridden
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Vasculitis (inflammation of a blood vessel or blood vessels)
Blood cholesterol increased
Chest pain
Drug abuse

50-59:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Burning sensation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Delusion (a false belief or opinion)
Disturbance in attention
Dizziness
Dry mouth
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)

60+:

Death
Vomiting
Mitral valve incompetence (inefficient heart valve)
Oedema peripheral (superficial swelling)
Pyrexia (fever)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Tricuspid valve incompetence (inefficient heart valve)
Abdominal distension
Abdominal pain

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 30 people, 40.00%
Insomnia (sleeplessness): 16 people, 21.33%
High Blood Cholesterol: 15 people, 20.00%
Chest Pain: 15 people, 20.00%
Diabetes: 14 people, 18.67%
Cardiac Disorder: 14 people, 18.67%
Migraine (headache): 14 people, 18.67%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 14 people, 18.67%
Muscle Spasms (muscle contraction): 13 people, 17.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 17.33%

* Approximation only. Some reports may have incomplete information.

Do you take Lomotil and Tylenol w/ codeine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously