Lonox and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonox (atropine sulfate; diphenoxylate hydrochloride) and Ibu (ibuprofen). Common drug interactions include vomiting among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Lonox and Ibu. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Lonox?

Lonox has active ingredients of atropine sulfate; diphenoxylate hydrochloride. eHealthMe is studying from 376 Lonox users. Check the latest studies of Lonox.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

On Jul, 16, 2026

35 people who take Lonox and Ibu together, and have interactions are studied.

What are the common drug interactions of Lonox and Ibu, by gender? *:

female:

Vomiting
Abdominal distension
Foot fracture
Arthralgia (joint pain)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Depression
Emotional distress
Hepatic enzyme increased
Hypoaesthesia (reduced sense of touch or sensation)

male:

Diarrhoea
Vomiting
Anaemia of malignant disease
Anaemia vitamin b12 deficiency
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Balance disorder
Biliary dilatation
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)

What are the common drug interactions of Lonox and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Decreased appetite
Diarrhoea
Eating disorder
Gallbladder disorder
Irritable bowel syndrome
Nausea (feeling of having an urge to vomit)
Vomiting
Weight decreased

20-29:

n/a

30-39:

n/a

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hyperthyroidism (over activity of the thyroid gland)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Neck pain
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Epistaxis (bleed from the nose)
Anger
Asthenia (weakness)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)

50-59:

Foot fracture
Nausea (feeling of having an urge to vomit)
Vomiting
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Depression
Emotional distress
Hypoaesthesia (reduced sense of touch or sensation)
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Anxiety
Emotional distress
Balance disorder
Biliary dilatation
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
Bone pain
Carcinoid syndrome (syndrome includes flushing and diarrhoea, and, less frequently, heart failure and bronchoconstriction)
Carcinoid tumour of the small bowel
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 5 people, 14.29%
Hiv Infection: 4 people, 11.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.57%
Diarrhea: 3 people, 8.57%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 8.57%
Type 2 Diabetes: 2 people, 5.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.71%
Nausea (feeling of having an urge to vomit): 2 people, 5.71%
High Blood Pressure: 2 people, 5.71%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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