Lonsurf and Lactulose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Lactulose (lactulose). Common drug interactions include cachexia among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Lactulose. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Lactulose?

Lactulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 46,960 Lactulose users. Check the latest studies of Lactulose.

On Jul, 17, 2026

85 people who take Lonsurf and Lactulose together, and have interactions are studied.

Lonsurf and Lactulose drug interactions.

What are the common drug interactions of Lonsurf and Lactulose, by gender? *:

female:

Cachexia (loss of weight)
Cough
Dyspnoea (difficult or laboured respiration)
Gastritis (inflammation of stomach)
Metastases to peritoneum (cancer spreads to peritoneum)
Neutropenic colitis (inflammation of the cecum, often with involvement of the ascending colon and ileum, a life threatening condition)
Pain in extremity
Platelet count decreased
Pneumonia
Alopecia (absence of hair from areas of the body)

male:

Death
Nausea (feeling of having an urge to vomit)
White blood cell count decreased
Malaise (a feeling of general discomfort or uneasiness)
Dyspnoea (difficult or laboured respiration)
Weight decreased
Asthenia (weakness)
Pyrexia (fever)
Abdominal discomfort
Carcinoembryonic antigen increased

What are the common drug interactions of Lonsurf and Lactulose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Death
Alopecia (absence of hair from areas of the body)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Red blood cell count decreased
Urinary retention (the inability to completely or partially empty the bladder)

40-49:

Decreased appetite
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Pain
Peripheral sensory neuropathy (damage to one or more of your peripheral nerves)
Death
Abdominal pain
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Blood bilirubin increased

50-59:

Headache (pain in head)
Immunoglobulins decreased
Lymphocyte count decreased
Malignant neoplasm progression (cancer tumour came back)
Monocyte count decreased
Neuropathy peripheral (surface nerve damage)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Red blood cell count decreased
Red cell distribution width increased
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Death
Disease progression
Intestinal obstruction
Malaise (a feeling of general discomfort or uneasiness)
Neutropenia (an abnormally low number of neutrophils)
Pain
White blood cell count decreased
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Confusional state
Diarrhoea

What are the existing conditions these people have? *

Colon Cancer: 41 people, 48.24%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 13 people, 15.29%
Pain: 9 people, 10.59%
Rectal Cancer (cancer of rectum): 6 people, 7.06%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 6 people, 7.06%
Nausea (feeling of having an urge to vomit): 5 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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