Lonsurf and Oxycodone hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Oxycodone hydrochloride (oxycodone hydrochloride). Common drug interactions include dehydration among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Oxycodone hydrochloride. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

On Jul, 07, 2026

22 people who take Lonsurf and Oxycodone hydrochloride together, and have interactions are studied.

Lonsurf and Oxycodone hydrochloride drug interactions.

What are the common drug interactions of Lonsurf and Oxycodone Hydrochloride, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Renal failure (kidney dysfunction)
Chest pain
Hypertension (high blood pressure)
Neutropenia (an abnormally low number of neutrophils)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Diarrhoea
Hysterectomy
Rhinorrhoea (watery mucus discharge from the nose)
Abdominal adhesions (inflammation of abdomen)

male:

Death
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Sepsis (a severe blood infection that can lead to organ failure and death)
Spinal pain (pain in spine)
Folliculitis (infection of hair root)
Haemoglobin decreased

What are the common drug interactions of Lonsurf and Oxycodone Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Metastases to lymph nodes (cancer spreads to lymph node)
Nausea (feeling of having an urge to vomit)
Death
Enterocolitis haemorrhagic (bleeding and inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)

50-59:

Death
Dyspnoea (difficult or laboured respiration)
Lymphangiosis carcinomatosa (inflammation of the lymph vessels can lead to cancer)
Myelosuppression (a decrease in the production of blood cells)
Anaemia (lack of blood)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Neutropenia (an abnormally low number of neutrophils)

60+:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Death
Abdominal adhesions (inflammation of abdomen)
Abdominal pain
Biliary dilatation
Biliary obstruction
Carcinoembryonic antigen increased
Catheter site pain
Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts)
Disease progression

What are the existing conditions these people have? *

Colon Cancer: 13 people, 59.09%
Oesophageal Carcinoma (cancer tumour of oesophagus): 3 people, 13.64%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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