Lonsurf and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Reglan (metoclopramide hydrochloride). Common drug interactions include disease progression among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Reglan. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

On Jul, 26, 2026

51 people who take Lonsurf and Reglan together, and have interactions are studied.

What are the common drug interactions of Lonsurf and Reglan, by gender? *:

female:

Disease progression
Malaise (a feeling of general discomfort or uneasiness)
Diarrhoea
Vomiting
Asthenia (weakness)
Death
Drug ineffective
Dry skin
Fatigue (feeling of tiredness)
Dehydration (dryness resulting from the removal of water)

male:

Fatigue (feeling of tiredness)
Death
Haemoglobin decreased
Pyrexia (fever)
Confusional state
Fungal infection
Infection
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Bile duct stone

What are the common drug interactions of Lonsurf and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Death
Disease progression
Abdominal distension
Abdominal pain lower
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

50-59:

Disease progression
Malaise (a feeling of general discomfort or uneasiness)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Death
Drug ineffective
Hypoxia (low oxygen in tissues)
Surgery
Confusional state
Fungal infection

60+:

Fatigue (feeling of tiredness)
Vomiting
Death
Dry skin
Syncope (loss of consciousness with an inability to maintain postural tone)
Decreased appetite
Malaise (a feeling of general discomfort or uneasiness)
Abdominal pain
Contusion (a type of hematoma of tissue in which capillaries)
Feeding disorder (when children refuse to eat certain food groups)

What are the existing conditions these people have? *

Colon Cancer: 27 people, 52.94%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 6 people, 11.76%
Pain: 5 people, 9.80%
Rectal Cancer Metastatic (cancer of rectum spreads to other): 4 people, 7.84%
Nausea (feeling of having an urge to vomit): 4 people, 7.84%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 4 people, 7.84%
Rectal Cancer (cancer of rectum): 3 people, 5.88%
Nausea And Vomiting: 3 people, 5.88%
Colorectal Cancer Stage Iv (cancer of colon and rectal spreads to liver or lung): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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