Lonsurf and Sertraline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Sertraline (sertraline hydrochloride). Common drug interactions include glossodynia among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Sertraline. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,304 Sertraline users. Check the latest studies of Sertraline.

On Jul, 10, 2026

82 people who take Lonsurf and Sertraline together, and have interactions are studied.

Lonsurf and Sertraline drug interactions.

What are the common drug interactions of Lonsurf and Sertraline, by gender? *:

female:

Glossodynia (a burning or painful sensation in the tongue)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic failure (liver failure)
Hospitalisation
Joint swelling
Lethargy (tiredness)
Malignant pleural effusion (a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue lining of lung)
Memory impairment
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)

male:

Fatigue (feeling of tiredness)
Diarrhoea
Vomiting
Abdominal pain upper
Thrombocytopenia (decrease of platelets in blood)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Arthralgia (joint pain)
Blood bilirubin increased
Haematochezia (passage of stools containing blood)

What are the common drug interactions of Lonsurf and Sertraline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Death
Disease progression

50-59:

Disease progression
Asthenia (weakness)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Ascites (accumulation of fluid in the abdominal cavity)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Blood bilirubin increased
Blood pressure decreased
Cancer pain
Constipation

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Pyrexia (fever)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Anaemia (lack of blood)
Blood bilirubin increased
Intestinal obstruction
Muscular weakness (muscle weakness)
Oedema (fluid collection in tissue)

What are the existing conditions these people have? *

Colon Cancer: 42 people, 51.22%
Rectal Cancer (cancer of rectum): 13 people, 15.85%
Pain: 10 people, 12.20%
Constipation: 8 people, 9.76%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 7 people, 8.54%
Nausea (feeling of having an urge to vomit): 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

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