Lonsurf and Tessalon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lonsurf (tipiracil hydrochloride; trifluridine) and Tessalon (benzonatate). Common drug interactions include decreased appetite among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Lonsurf and Tessalon. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Lonsurf?

Lonsurf has active ingredients of tipiracil hydrochloride; trifluridine. eHealthMe is studying from 10,077 Lonsurf users. Check the latest studies of Lonsurf.

What is Tessalon?

Tessalon has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 6,493 Tessalon users. Check the latest studies of Tessalon.

On Jul, 08, 2026

19 people who take Lonsurf and Tessalon together, and have interactions are studied.

What are the common drug interactions of Lonsurf and Tessalon, by gender? *:

female:

Decreased appetite
Pyrexia (fever)
Weight decreased
Neuralgia (pain in one or more nerves)
Nausea (feeling of having an urge to vomit)
Vomiting
Alopecia (absence of hair from areas of the body)
Blood potassium decreased
Diarrhoea
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)

male:

Fatigue (feeling of tiredness)
Hepatic neoplasm (liver tumour)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
White blood cell count decreased
Disease progression
Death
Pathological fracture (broken bone caused by disease)
Spinal cord compression

What are the common drug interactions of Lonsurf and Tessalon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Agitation (state of anxiety or nervous excitement)
Fatigue (feeling of tiredness)
Oral pain

50-59:

Death
Drug ineffective

60+:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Red blood cell count decreased
Vomiting
Weight decreased
Disease progression
Hepatic neoplasm (liver tumour)
Death
Laryngitis (inflammation of the larynx)
Constipation

What are the existing conditions these people have? *

Colon Cancer: 9 people, 47.37%
Rectal Cancer (cancer of rectum): 5 people, 26.32%
Skin Irritation: 2 people, 10.53%
High Blood Pressure: 2 people, 10.53%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.26%
Thyroid Cancer: 1 person, 5.26%
Rectosigmoid Cancer (cancer that originates in the rectum and sigmoid colon): 1 person, 5.26%
Malignant Anorectal Neoplasm (cancerous tumour of anus or rectum): 1 person, 5.26%
Gastric Cancer (stomach cancer): 1 person, 5.26%
Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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