Loperamide hydrochloride and Centrum drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loperamide hydrochloride (loperamide hydrochloride) and Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include drug ineffective among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Loperamide hydrochloride and Centrum. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Loperamide hydrochloride?

Loperamide hydrochloride has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 10,814 Loperamide hydrochloride users. Check the latest studies of Loperamide hydrochloride.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

35 people who take Loperamide hydrochloride and Centrum together, and have interactions are studied.

Loperamide hydrochloride and Centrum drug interactions.

What are the common drug interactions of Loperamide Hydrochloride and Centrum, by gender? *:

female:

Drug ineffective
Constipation
Oesophagitis (inflammation of oesophagus)
Vomiting
Bacteraemia (presence of bacteria in the blood)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Decreased appetite
Dizziness
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Nausea (feeling of having an urge to vomit)

male:

Abdominal distension
Ascites (accumulation of fluid in the abdominal cavity)
Dehydration (dryness resulting from the removal of water)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Drug effect delayed
Drug ineffective
Dysphonia (speech disorder attributable to a disorder of phonation)
Ear infection
Ear neoplasm malignant (ear cancerous tumour)
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)

What are the common drug interactions of Loperamide Hydrochloride and Centrum, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Chest pain
Intermenstrual bleeding
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Abdominal distension
Abdominal pain
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood creatinine increased
Blood urea increased
Confusional state

50-59:

Ascites (accumulation of fluid in the abdominal cavity)
Dyspnoea (difficult or laboured respiration)
Oedema lower limb (fluid collection in tissue of lower leg)
Abdominal distension
Blood bilirubin increased
Hepatic failure (liver failure)
Hepatic function abnormal

60+:

Drug ineffective
Constipation
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Bone pain
Burning sensation
Chills (felling of cold)
Colitis (inflammation of colon)
Contusion (a type of hematoma of tissue in which capillaries)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 5 people, 14.29%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 14.29%
Thyroid Cancer: 4 people, 11.43%
Neoplasm Malignant (cancer tumour): 4 people, 11.43%
High Blood Pressure: 4 people, 11.43%
Affective Disorder (mental disorder): 4 people, 11.43%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 8.57%
Primary Myelofibrosis (primary disorder of the bone marrow): 3 people, 8.57%
Muscle Spasms (muscle contraction): 3 people, 8.57%
Diabetes: 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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