Loperamide hydrochloride and Nitrostat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loperamide hydrochloride (loperamide hydrochloride) and Nitrostat (nitroglycerin). Common drug interactions include pain among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Loperamide hydrochloride and Nitrostat. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Loperamide hydrochloride?

Loperamide hydrochloride has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 10,814 Loperamide hydrochloride users. Check the latest studies of Loperamide hydrochloride.

What is Nitrostat?

Nitrostat has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 14,082 Nitrostat users. Check the latest studies of Nitrostat.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

29 people who take Loperamide hydrochloride and Nitrostat together, and have interactions are studied.

Loperamide hydrochloride and Nitrostat drug interactions.

What are the common drug interactions of Loperamide Hydrochloride and Nitrostat, by gender? *:

female:

Pain
Chronic kidney disease
Renal failure (kidney dysfunction)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Alopecia (absence of hair from areas of the body)
Aortic valve stenosis (narrowing of the aortic valve)
Biliary cirrhosis primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver)
Cardiac failure congestive
Cerebrovascular disorder (disease of brain)
Coma (state of unconsciousness lasting more than six hours)

male:

Death
Fall
Bone density decreased
Chronic kidney disease
Drug intolerance (drug sensitivity)
Emotional distress
Exercise tolerance decreased
Faeces discoloured
Febrile neutropenia (fever with reduced white blood cells)
Hospitalisation

What are the common drug interactions of Loperamide Hydrochloride and Nitrostat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Aspergillosis (an infection caused by a fungus called aspergillus)
Febrile neutropenia (fever with reduced white blood cells)
Immunosuppression
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

20-29:

n/a

30-39:

n/a

40-49:

Bone density decreased
Chronic kidney disease
Emotional distress
Exercise tolerance decreased
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypertension (high blood pressure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

50-59:

Faeces discoloured

60+:

Pain
Chronic kidney disease
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Aortic valve stenosis (narrowing of the aortic valve)
Asthenia (weakness)
Biliary cirrhosis primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver)
Cardiac failure congestive
Cerebrovascular disorder (disease of brain)
Coma (state of unconsciousness lasting more than six hours)
Drug intolerance (drug sensitivity)

What are the existing conditions these people have? *

Stress And Anxiety: 9 people, 31.03%
Depression: 9 people, 31.03%
Migraine (headache): 9 people, 31.03%
Hypersensitivity: 7 people, 24.14%
Cough: 7 people, 24.14%
Dry Eyes (lack of adequate tears): 7 people, 24.14%
Pain: 6 people, 20.69%
Herpes Zoster: 5 people, 17.24%
Joint Pain: 5 people, 17.24%
Irritable Bowel Syndrome: 5 people, 17.24%

* Approximation only. Some reports may have incomplete information.

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