Lopid and Macrodantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lopid (gemfibrozil) and Macrodantin (nitrofurantoin, macrocrystalline). Common drug interactions include weight increased among females.

The phase IV clinical study analyzes what interactions people have when they take Lopid and Macrodantin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Lopid?

Lopid has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 9,700 Lopid users. Check the latest studies of Lopid.

What is Macrodantin?

Macrodantin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 3,755 Macrodantin users. Check the latest studies of Macrodantin.

On Jul, 10, 2026

17 people who take Lopid and Macrodantin together, and have interactions are studied.

Lopid and Macrodantin drug interactions.

What are the common drug interactions of Lopid and Macrodantin, by gender? *:

female:

Weight increased
Neuropathy peripheral (surface nerve damage)
Asthenia (weakness)
Back pain
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drooling (drop saliva uncontrollably from the mouth)
Drug hypersensitivity

male:

n/a

What are the common drug interactions of Lopid and Macrodantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Neuropathy peripheral (surface nerve damage)
Type 2 diabetes mellitus
Weight increased

40-49:

Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Eyelid ptosis (falling of the upper or lower eyelid)
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Fluid retention (an abnormal accumulation of fluid in the blood)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Frustration (a form of poorly expressed anger)
Gastric mucosal hypertrophy (inflammation and ulcers (breaks on the skin or on the surface of an organ) of the mucosa (inner lining) of the stomach)

50-59:

Agitation (state of anxiety or nervous excitement)
Drooling (drop saliva uncontrollably from the mouth)
Psychotic disorder
Somnolence (a state of near-sleep, a strong desire for sleep)
Disturbance in attention
Vision blurred

60+:

Fall
Abdominal pain
Fluid retention (an abnormal accumulation of fluid in the blood)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Pain
Skin ulcer
Weight increased
Accident
Angina pectoris (chest pain due to ischemia of the heart muscle)

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 8 people, 47.06%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 2 people, 11.76%
Pain: 2 people, 11.76%
Chest Pain: 2 people, 11.76%
Back Pain: 2 people, 11.76%
Pulmonary Congestion (congestion in the lungs): 1 person, 5.88%
Impaired Gastric Emptying: 1 person, 5.88%
Cough: 1 person, 5.88%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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