Lopurin and Symlin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lopurin (allopurinol) and Symlin (pramlintide acetate). Common drug interactions include gastroenteritis viral among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Lopurin and Symlin. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Lopurin?

Lopurin has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,798 Lopurin users. Check the latest studies of Lopurin.

What is Symlin?

Symlin has active ingredients of pramlintide acetate. It is often used in diabetes. eHealthMe is studying from 3,359 Symlin users. Check the latest studies of Symlin.

On Jul, 30, 2026

56 people who take Lopurin and Symlin together, and have interactions are studied.

What are the common drug interactions of Lopurin and Symlin, by gender? *:

female:

Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Vomiting
Arrhythmia (irregular heartbeat)
Blood pressure increased
Chest discomfort
Heart rate increased
Constipation
Depression
Diarrhoea
Dyspepsia (indigestion)

male:

Nausea (feeling of having an urge to vomit)
Weight decreased
Oesophagitis (inflammation of oesophagus)
Pancreatitis (inflammation of pancreas)
Renal failure acute (rapid kidney dysfunction)
Urine output decreased
Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Arthralgia (joint pain)
Blood cholesterol increased

What are the common drug interactions of Lopurin and Symlin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Decreased appetite
Dizziness
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)

40-49:

Chronic kidney disease
Confusional state
Dry mouth
Early satiety (feeling full before completing a normal sized meal)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Retching (strong involuntary effort to vomit)
Vomiting
Weight decreased

50-59:

Hypoaesthesia facial (reduced sense of touch or sensation on face)
Hypotension (abnormally low blood pressure)
Hysterectomy
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Neuropathy peripheral (surface nerve damage)
Osteoporosis (bones weak and more likely to break)
Pain in extremity
Pancreatitis acute (sudden inflammation of pancreas)
Pelvic pain
Renal injury (kidney injury)

60+:

Blood glucose increased
Weight decreased
Renal failure acute (rapid kidney dysfunction)
Vomiting
Urine output decreased
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Hallucination (an experience involving the perception of something not present)
Hypovolaemia (a decreased volume of circulating blood in the body)
Localised infection (infection at the single location)
Decreased appetite

What are the existing conditions these people have? *

Type 2 Diabetes: 30 people, 53.57%
High Blood Cholesterol: 17 people, 30.36%
Pain: 14 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 23.21%
Blood Pressure Abnormal: 11 people, 19.64%
Cardiac Disorder: 11 people, 19.64%
Sleep Disorder: 10 people, 17.86%
Kidney Stones: 7 people, 12.50%
Depression: 5 people, 8.93%
High Blood Pressure: 5 people, 8.93%

* Approximation only. Some reports may have incomplete information.

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