Lopurin and Xigduo xr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lopurin (allopurinol) and Xigduo xr (dapagliflozin propanediol; metformin hydrochloride). Common drug interactions include pruritus among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Lopurin and Xigduo xr. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Lopurin?

Lopurin has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,797 Lopurin users. Check the latest studies of Lopurin.

What is Xigduo xr?

Xigduo xr has active ingredients of dapagliflozin propanediol; metformin hydrochloride. eHealthMe is studying from 2,917 Xigduo xr users. Check the latest studies of Xigduo xr.

On Jul, 05, 2026

57 people who take Lopurin and Xigduo xr together, and have interactions are studied.

Lopurin and Xigduo xr drug interactions.

What are the common drug interactions of Lopurin and Xigduo Xr, by gender? *:

female:

Pruritus (severe itching of the skin)
Rash papular (redness with papule)
Vulvovaginal pruritus (vulvovaginal severe itching)
Arthralgia (joint pain)
Asthma
Breath sounds
Chest discomfort
Chest pain
Cough
Dyspnoea exertional (breathlessness or shortness of breath)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess (pus)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Emphysematous pyelonephritis (presence of gas-producing bacteria in the kidney)
Constipation
Diarrhoea
Injection site extravasation (flow of (blood or lymph) from injection site)
Anaemia (lack of blood)
Asthenia (weakness)
Blood glucose decreased

What are the common drug interactions of Lopurin and Xigduo Xr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Arthralgia (joint pain)
Asthma
Breath sounds
Chest discomfort
Chest pain
Cough
Dyspnoea exertional (breathlessness or shortness of breath)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Respiratory tract infection
Urinary incontinence (inability to control the flow of urine and involuntary urination)

30-39:

Dermoid cyst (an abnormal growth (teratoma) containing epidermis, hair follicles, and sebaceous glands)
Anal abscess

40-49:

Dizziness
Hypoaesthesia (reduced sense of touch or sensation)
Chronic kidney disease
Renal impairment (severely reduced kidney function)
Asthenia (weakness)
Constipation
Diabetic foot
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Limb injury
Muscle strain (an injury to a muscle in which the muscle fibres tear)

50-59:

Abscess (pus)
Abscess neck (neck abscesses)
Anal abscess
Cellulitis (infection under the skin)
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Left ventricular dysfunction

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Emphysematous pyelonephritis (presence of gas-producing bacteria in the kidney)
Anaemia (lack of blood)
Blood glucose decreased
Blood pressure increased
Decreased appetite
Dysgeusia (disorder of the sense of taste)
Dyspepsia (indigestion)
Fluid intake reduced
Fluid retention (an abnormal accumulation of fluid in the blood)

What are the existing conditions these people have? *

Diabetes: 19 people, 33.33%
Type 2 Diabetes: 18 people, 31.58%
High Blood Pressure: 16 people, 28.07%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 14.04%
High Blood Cholesterol: 7 people, 12.28%
Iron Deficiency: 6 people, 10.53%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 6 people, 10.53%
Hypokalemia (low potassium): 5 people, 8.77%
Neuralgia (pain in one or more nerves): 5 people, 8.77%
Seasonal Allergy (allergic condition due to certain season): 5 people, 8.77%

* Approximation only. Some reports may have incomplete information.

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