Loraz and Disulfiram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loraz (lorazepam) and Disulfiram (disulfiram). Common drug interactions include gastric ulcer among females and depressed mood among males.

The phase IV clinical study analyzes what interactions people have when they take Loraz and Disulfiram. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,694 Loraz users. Check the latest studies of Loraz.

What is Disulfiram?

Disulfiram has active ingredients of disulfiram. It is often used in alcoholism. eHealthMe is studying from 1,245 Disulfiram users. Check the latest studies of Disulfiram.

On Jul, 27, 2026

78 people who take Loraz and Disulfiram together, and have interactions are studied.

What are the common drug interactions of Loraz and Disulfiram, by gender? *:

female:

Gastric ulcer (stomach ulcer)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Lethargy (tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Mydriasis (a dilation of the pupil)
Nasopharyngitis (inflammation of the nasopharynx)
Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Oesophagitis (inflammation of oesophagus)

male:

Depressed mood
Drug abuse
Suicidal ideation
Dissociative disorder
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Panic attack
Lactic acidosis (low ph in body tissues)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Confusional state
Multi-organ failure (multisystem organ failure)

What are the common drug interactions of Loraz and Disulfiram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chronic kidney disease
Psychotic disorder

30-39:

Overdose
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Respiratory depression (respiration has a rate below 12 breaths)
Alcohol withdrawal syndrome
Anticholinergic syndrome (absolute or relative reduction in cholinergic activity in the central nervous system)
Loss of consciousness
Staphylococcal infection (an infection with staphylococcus bacteria)
Sputum culture positive
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Agitation (state of anxiety or nervous excitement)

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Death
Delirium (wild excitement)
Drug administration error
Drug toxicity
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)
Gastritis (inflammation of stomach)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatitis alcoholic (inflammation of the liver due to alcohol)

50-59:

Drug abuse
Intentional self-injury
Sopor (sleep)
Abdominal pain upper
Gastric ulcer (stomach ulcer)
Malaise (a feeling of general discomfort or uneasiness)
Oesophagitis (inflammation of oesophagus)
Vomiting
Abdominal distension
Abdominal pain

60+:

Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
Decreased appetite
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Panic attack
Suicidal ideation
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Agitation (state of anxiety or nervous excitement)
Blood creatine phosphokinase increased
Blood pressure fluctuation

What are the existing conditions these people have? *

Hiv Infection: 9 people, 11.54%
High Blood Pressure: 9 people, 11.54%
Neuropathy Peripheral (surface nerve damage): 7 people, 8.97%
Insomnia (sleeplessness): 6 people, 7.69%
Sleep Disorder: 5 people, 6.41%
Depression: 5 people, 6.41%

* Approximation only. Some reports may have incomplete information.

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