Loraz and Optimark drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loraz (lorazepam) and Optimark (gadoversetamide). Common drug interactions include injury among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Loraz and Optimark. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,694 Loraz users. Check the latest studies of Loraz.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

On Jul, 15, 2026

24 people who take Loraz and Optimark together, and have interactions are studied.

What are the common drug interactions of Loraz and Optimark, by gender? *:

female:

Injury
Joint range of motion decreased (disease of joint movement)
Pruritus (severe itching of the skin)
Skin fibrosis (fibrous tissue formation on skin)
Emotional distress
Skin lesion
Erythema (redness of the skin)
Pain in extremity
Skin burning sensation
Muscular weakness (muscle weakness)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Abasia (inability to walk)
Burning sensation
Gait disturbance
Joint contracture (a permanent shortening of a muscle or joint)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)

What are the common drug interactions of Loraz and Optimark, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abscess limb (limb infection)
Asthma
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood bilirubin decreased
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cardiac failure acute
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Coagulopathy (blood's ability to clot is impaired)

40-49:

Oedema peripheral (superficial swelling)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Skin hypertrophy (skin cells enlarges)
Pruritus (severe itching of the skin)
Skin fibrosis (fibrous tissue formation on skin)
Skin induration (an abnormally hard spot or area on the skin)
General physical health deterioration (weak health status)
Skin discolouration (change of skin colour)
Skin lesion

50-59:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Hepatomegaly (abnormal enlargement of the liver)
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hypertension (high blood pressure)
Hypertensive heart disease
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries))
Hypokalaemia (low potassium)

60+:

Emotional distress
Injury
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Mitochondrial toxicity (a condition in which the mitochondria of a body's cells become damaged or decline significantly in number;)
Muscle contracture (a permanent shortening of a muscle)
Muscular weakness (muscle weakness)
Nontherapeutic agent urine positive
Oedema peripheral (superficial swelling)
Skin hypertrophy (skin cells enlarges)
Mobility decreased (ability to move is reduced)

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 9 people, 37.50%
Nuclear Magnetic Resonance Imaging Abdominal: 3 people, 12.50%
Wound Complication: 2 people, 8.33%
Neuralgia (pain in one or more nerves): 2 people, 8.33%
Insomnia (sleeplessness): 2 people, 8.33%
Anaemia (lack of blood): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Loraz and Optimark?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously