Loraz and Zofran odt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Loraz (lorazepam) and Zofran odt (ondansetron). Common drug interactions include oedema peripheral among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Loraz and Zofran odt. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Loraz?

Loraz has active ingredients of lorazepam. It is often used in stress and anxiety. eHealthMe is studying from 165,694 Loraz users. Check the latest studies of Loraz.

What is Zofran odt?

Zofran odt has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 2,092 Zofran odt users. Check the latest studies of Zofran odt.

On Jul, 15, 2026

55 people who take Loraz and Zofran odt together, and have interactions are studied.

What are the common drug interactions of Loraz and Zofran Odt, by gender? *:

female:

Oedema peripheral (superficial swelling)
Oral pain
Pancreatitis acute (sudden inflammation of pancreas)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Rash
Rash papular (redness with papule)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Splenomegaly (enlargement of spleen)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

male:

Asthenia (weakness)
Cardiac disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Carcinoid heart disease (heart valve disease)
Confusional state
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Death
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hemiparesis (weakness on one side of the body)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)

What are the common drug interactions of Loraz and Zofran Odt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Stomatitis (inflammation of mucous membrane of mouth)

10-19:

n/a

20-29:

Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Infection
Neoplasm progression (growth of tumour)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Dry mouth
Oral pain

40-49:

Fall
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nightmare (unpleasant dream)
Pruritus (severe itching of the skin)
Burning sensation
Eye disorder
Gait disturbance
Hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Lethargy (tiredness)

50-59:

Abdominal pain
Drug ineffective
Hangover
Migraine (headache)
Muscular weakness (muscle weakness)
Muscle tightness
Oral disorder (mouth disease)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Grip strength decreased
Bacteraemia (presence of bacteria in the blood)

60+:

Pneumonia
Asthenia (weakness)
Fatigue (feeling of tiredness)
Malignant neoplasm progression (cancer tumour came back)
Cardiac valve disease (heart valve disease)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Cystitis (inflammation of the wall of the bladder)
Drug resistance (reduction in effectiveness of a drug)
Embolic stroke (stroke due to obstruction due to an embolus)
Klebsiella test positive

What are the existing conditions these people have? *

Pain: 16 people, 29.09%
Constipation: 13 people, 23.64%
Nausea And Vomiting: 8 people, 14.55%
Breast Cancer: 6 people, 10.91%
Multiple Myeloma (cancer of the plasma cells): 6 people, 10.91%
Dyspnea (difficult or laboured breathing): 5 people, 9.09%
High Blood Pressure: 5 people, 9.09%
Insomnia (sleeplessness): 5 people, 9.09%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 7.27%
Allergic Rhinitis: 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

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