Lorcet-hd and Rocephin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lorcet-hd (acetaminophen; hydrocodone bitartrate) and Rocephin (ceftriaxone sodium). Common drug interactions include lung hyperinflation among females and bronchitis among males.

The phase IV clinical study analyzes what interactions people have when they take Lorcet-hd and Rocephin. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

On Jul, 16, 2026

28 people who take Lorcet-hd and Rocephin together, and have interactions are studied.

Lorcet-hd and Rocephin drug interactions.

What are the common drug interactions of Lorcet-Hd and Rocephin, by gender? *:

female:

Lung hyperinflation (inspiration of more than normal)
Lung neoplasm (tumour of lung)
Muscle spasms (muscle contraction)
Nephrosclerosis (hardening of the kidney due to renovascular disease)
Oral disorder (mouth disease)
Oral infection
Oral mucosal exfoliation (removal of mucous membrane of mouth)
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

male:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Abdominal pain
Lip swelling
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neck pain
Oedema mouth (swelling of mouth)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Otitis media (inflammation of the middle ear)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Rash

What are the common drug interactions of Lorcet-Hd and Rocephin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug abuser
Drug addiction
Abdominal distension
Abdominal pain
Abdominal tenderness
Abortion spontaneous (naturally occurring miscarriage)
Agitation (state of anxiety or nervous excitement)
Alcohol abuse
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

40-49:

Abdominal pain
Arthralgia (joint pain)
Blood pressure decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Chest discomfort
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Haemorrhage subcutaneous (bleeding from skin)

50-59:

Renal failure chronic (long lasting kidney dysfunction)
Sinusitis (inflammation of sinus)
Syncope (loss of consciousness with an inability to maintain postural tone)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Arthralgia (joint pain)
Anxiety
Biliary colic
Blood creatinine increased
Cervical spinal stenosis (narrowing of the spinal canal in the neck)

60+:

Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pleural effusion (water on the lungs)
Cardiogenic shock (inadequate circulation of blood)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Multiple injuries
Renal failure chronic (long lasting kidney dysfunction)
Vomiting

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 7 people, 25.00%
Back Pain: 7 people, 25.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 25.00%
Nausea (feeling of having an urge to vomit): 6 people, 21.43%
Depression: 5 people, 17.86%
Vaginal Bleeding Between Periods: 4 people, 14.29%
Rashes (redness): 4 people, 14.29%
Insomnia (sleeplessness): 4 people, 14.29%
Fungal Infection: 4 people, 14.29%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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