Lortab and Cyanocobalamin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Cyanocobalamin (cyanocobalamin). Common drug interactions include gastrointestinal haemorrhage among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Cyanocobalamin. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Cyanocobalamin?

Cyanocobalamin has active ingredients of cyanocobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 14,651 Cyanocobalamin users. Check the latest studies of Cyanocobalamin.

On Jul, 13, 2026

40 people who take Lortab and Cyanocobalamin together, and have interactions are studied.

Lortab and Cyanocobalamin drug interactions.

What are the common drug interactions of Lortab and Cyanocobalamin, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Haematoma (collection of blood outside the blood vessels)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Impaired gastric emptying
Increased upper airway secretion
Injection site pruritus (severe itching at injection site)
Injury

male:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Renal failure (kidney dysfunction)
Amyloidosis (a tumour within which amyloid is produced)
Anaemia (lack of blood)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Bone density decreased
Bone loss
Bone pain
Catheter site infection (infection at the site of insertion)

What are the common drug interactions of Lortab and Cyanocobalamin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anaemia (lack of blood)
Drug administration error
Dysphonia (speech disorder attributable to a disorder of phonation)
Fall
Femur fracture
Headache (pain in head)
Hip fracture
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Joint injury
Lower limb fracture

10-19:

n/a

20-29:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)

30-39:

Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)

40-49:

Drug hypersensitivity
Headache (pain in head)
Fall
Hypertensive crisis
Vomiting
Chronic kidney disease
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Blood pressure increased
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)

50-59:

Fall
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Hypertension (high blood pressure)
Increased upper airway secretion
Insomnia (sleeplessness)
Local swelling (swelling at the site of some application of substance or injury)

60+:

Aspartate aminotransferase increased
Syncope (loss of consciousness with an inability to maintain postural tone)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dental caries
Dental fistula
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dyspnoea (difficult or laboured respiration)
Exostosis (formation of new bone on the surface of a bone)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 15.00%
Nausea (feeling of having an urge to vomit): 5 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 12.50%
Depression: 4 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.00%
Sleep Disorder: 3 people, 7.50%
Asthma: 3 people, 7.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 7.50%
Insomnia (sleeplessness): 3 people, 7.50%
Indigestion: 3 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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