Lortab and Hydroxychloroquine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Hydroxychloroquine sulfate (hydroxychloroquine sulfate). Common drug interactions include anaemia among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Hydroxychloroquine sulfate. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Hydroxychloroquine sulfate?

Hydroxychloroquine sulfate has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. eHealthMe is studying from 52,084 Hydroxychloroquine sulfate users. Check the latest studies of Hydroxychloroquine sulfate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

41 people who take Lortab and Hydroxychloroquine sulfate together, and have interactions are studied.

Lortab and Hydroxychloroquine sulfate drug interactions.

What are the common drug interactions of Lortab and Hydroxychloroquine Sulfate, by gender? *:

female:

Anaemia (lack of blood)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Osteoporosis (bones weak and more likely to break)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Sinusitis (inflammation of sinus)
Dizziness
Drug ineffective

male:

Fall
Anaemia (lack of blood)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Oedema peripheral (superficial swelling)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Renal disorder (kidney disease)
Vomiting
Abdominal adhesions (inflammation of abdomen)

What are the common drug interactions of Lortab and Hydroxychloroquine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fall
Femur fracture
Foot fracture
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Joint dislocation (a joint position is changed from normal position)
Joint injury
Lower limb fracture
Nasopharyngitis (inflammation of the nasopharynx)
Osteoporosis (bones weak and more likely to break)
Patellofemoral pain syndrome (pain in the front of the knee)

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Erythema (redness of the skin)
Headache (pain in head)
Hypersensitivity
Injection site reaction
Pruritus (severe itching of the skin)
Sinus congestion (blockage of sinus)
Skin oedema (swelling of skin)
Skin warm

40-49:

Arthralgia (joint pain)
Oedema peripheral (superficial swelling)
Cataract (clouding of the lens inside the eye)
Drug ineffective
Fibromyalgia (a long-term condition which causes pain all over the body)
Herpes zoster
Immune system disorder
Joint swelling
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Thyroid neoplasm (tumour of thyroid)

50-59:

Arterial stenosis (abnormal narrowing of the aortic valve in the heart)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Bone disorder
Breast necrosis (death of cells or tissues through injury or disease in beast)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Chondropathy (disease of the cartilage)
Comminuted fracture (bone has broken into several pieces)
Constipation
Electrocardiogram st segment depression

60+:

Fall
Abdominal pain
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Oedema peripheral (superficial swelling)
Osteopenia (a condition where bone mineral density is lower than normal)
Type 2 diabetes mellitus

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 6 people, 14.63%
Hot Flush (sudden feelings of heat): 6 people, 14.63%
Metastases To Bone (cancer spreads to bone): 5 people, 12.20%
Breast Cancer: 5 people, 12.20%
Joint Pain: 3 people, 7.32%
Insomnia (sleeplessness): 3 people, 7.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.32%
Depression: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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