Lortab and Isosorbide mononitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Isosorbide mononitrate (isosorbide mononitrate). Common drug interactions include alopecia among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Isosorbide mononitrate. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Isosorbide mononitrate?

Isosorbide mononitrate has active ingredients of isosorbide mononitrate. It is often used in angina. eHealthMe is studying from 26,858 Isosorbide mononitrate users. Check the latest studies of Isosorbide mononitrate.

On Jul, 20, 2026

86 people who take Lortab and Isosorbide mononitrate together, and have interactions are studied.

Lortab and Isosorbide mononitrate drug interactions.

What are the common drug interactions of Lortab and Isosorbide Mononitrate, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Ankle fracture
Anxiety
Diarrhoea
Emotional distress
Headache (pain in head)
Humerus fracture (injury to the upper arm bone)
Limb crushing injury (crushing injury of upper limb)
Lower limb fracture
Muscle spasms (muscle contraction)

male:

Renal failure (kidney dysfunction)
Pneumonia
Subdural haematoma (blood collects between the skull and the surface of the brain)
Renal failure chronic (long lasting kidney dysfunction)
Gastrointestinal perforation (hole in the digestive tract)
Anaemia (lack of blood)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dementia (madness)
Febrile neutropenia (fever with reduced white blood cells)
General physical health deterioration (weak health status)

What are the common drug interactions of Lortab and Isosorbide Mononitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Renal failure (kidney dysfunction)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Chest pain
Decreased appetite
Diarrhoea
Dizziness
Hypotension (abnormally low blood pressure)
Nausea (feeling of having an urge to vomit)

50-59:

Humerus fracture (injury to the upper arm bone)
Limb crushing injury (crushing injury of upper limb)
Lower limb fracture
Nasopharyngitis (inflammation of the nasopharynx)
Osteoporosis (bones weak and more likely to break)
Radius fracture
Scar
Upper limb fracture
Anxiety
Depression

60+:

Pneumonia
Chronic kidney disease
Hypotension (abnormally low blood pressure)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dementia (madness)
Febrile neutropenia (fever with reduced white blood cells)
General physical health deterioration (weak health status)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 19.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 18.60%
Chest Pain: 8 people, 9.30%
High Blood Cholesterol: 8 people, 9.30%
Rashes (redness): 7 people, 8.14%
Constipation: 7 people, 8.14%
Depression: 7 people, 8.14%
Febrile Neutropenia (fever with reduced white blood cells): 6 people, 6.98%
Cardiac Disorder: 6 people, 6.98%
Thrombocytopenia (decrease of platelets in blood): 6 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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