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Lortab and Kalbitor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Kalbitor (ecallantide). Common drug interactions include viral infection among females and hereditary angioedema among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Kalbitor. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Kalbitor?

Kalbitor has active ingredients of ecallantide. eHealthMe is studying from 2,079 Kalbitor users. Check the latest studies of Kalbitor.

On Jul, 19, 2026

22 people who take Lortab and Kalbitor together, and have interactions are studied.

Lortab and Kalbitor drug interactions.

What are the common drug interactions of Lortab and Kalbitor, by gender? *:

female:

  1. Viral infection
  2. Vomiting
  3. Anaphylactic reaction (serious allergic reaction)
  4. Appendicitis (inflammation of the appendix)
  5. Disease recurrence
  6. Eating disorder
  7. Gastritis (inflammation of stomach)
  8. Hospitalisation
  9. Hypoaesthesia (reduced sense of touch or sensation)
  10. Local swelling (swelling at the site of some application of substance or injury)

male:

  1. Hereditary angioedema (recurrent episodes of severe swelling)
  2. Laryngeal oedema (swelling of larynx)

What are the common drug interactions of Lortab and Kalbitor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Anaphylactic reaction (serious allergic reaction)
  2. Dysphonia (speech disorder attributable to a disorder of phonation)
  3. Hereditary angioedema (recurrent episodes of severe swelling)
  4. Laryngeal oedema (swelling of larynx)

40-49:

  1. Hereditary angioedema (recurrent episodes of severe swelling)
  2. Sinusitis (inflammation of sinus)
  3. Hepatomegaly (abnormal enlargement of the liver)
  4. Infusion related reaction
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Nausea (feeling of having an urge to vomit)
  7. Renal disorder (kidney disease)
  8. Sinus disorder (disease of sinus)
  9. Splenic cyst (cyst on spleen or near by)
  10. Diarrhoea

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Hereditary Angioedema (recurrent episodes of severe swelling): 20 people, 90.91%
  2. Immune System Disorder: 9 people, 40.91%
  3. Headache (pain in head): 3 people, 13.64%
  4. Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Lortab and Kalbitor?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Lortab and Kalbitor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lortab:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Kalbitor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lortab and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Kalbitor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate and ecallantide (the active ingredients of Lortab and Kalbitor, respectively), and Lortab and Kalbitor (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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