Lortab and Milk thistle drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Milk thistle (milk thistle). Common drug interactions include dizziness among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Milk thistle. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Milk thistle?

Milk thistle has active ingredients of milk thistle. It is often used in fatty liver. eHealthMe is studying from 5,057 Milk thistle users. Check the latest studies of Milk thistle.

On Aug, 01, 2026

24 people who take Lortab and Milk thistle together, and have interactions are studied.

Lortab and Milk thistle drug interactions.

What are the common drug interactions of Lortab and Milk Thistle, by gender? *:

female:

Dizziness
Diarrhoea
Anxiety
Cardiac failure congestive
Constipation
Dehydration (dryness resulting from the removal of water)
Depression
Drug ineffective
Fall
Fluid overload (too much fluid in the blood)

male:

Decreased appetite
Weight decreased
Blood alkaline phosphatase increased
Blood bilirubin increased
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Gamma-glutamyltransferase increased
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypertension (high blood pressure)
Hyperuricaemia (level of uric acid in the blood that is abnormally high)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)

What are the common drug interactions of Lortab and Milk Thistle, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cough
Diarrhoea
Insomnia (sleeplessness)
Oral disorder (mouth disease)
Poor quality sleep
Respiratory tract congestion (blockage on respiratory system)
Sneezing

50-59:

Arthropathy
Blood cholesterol decreased
Constipation
Dizziness
Drug ineffective
Myalgia (muscle pain)
Osteoporosis (bones weak and more likely to break)
Overweight
Weight decreased
Anxiety

60+:

Diarrhoea
Dizziness
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Breast abscess
Decreased appetite
Disseminated intravascular coagulation (systemic activation of blood coagulation)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 20.83%
High Blood Pressure: 4 people, 16.67%
Breast Infection: 3 people, 12.50%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 12.50%
Nausea (feeling of having an urge to vomit): 3 people, 12.50%
Stress And Anxiety: 2 people, 8.33%
Muscle Spasms (muscle contraction): 2 people, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Lortab and Milk thistle?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously