Lortab and Mupirocin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Mupirocin (mupirocin). Common drug interactions include deep vein thrombosis among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Mupirocin. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Mupirocin?

Mupirocin has active ingredients of mupirocin. It is often used in impetigo. eHealthMe is studying from 5,940 Mupirocin users. Check the latest studies of Mupirocin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

45 people who take Lortab and Mupirocin together, and have interactions are studied.

What are the common drug interactions of Lortab and Mupirocin, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Glaucoma (increased fluid pressure in the eye with vision loss)
Neuropathy peripheral (surface nerve damage)
Purpura senile (skin condition in which areas of the skin develop a purplish or reddish-brown appearance due to bleeding of small blood vessels underneath)
Resorption bone increased
Tarsal tunnel syndrome (a condition that is caused by compression of the tibial nerve or its associated branches as the nerve)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Vasculitis (inflammation of a blood vessel or blood vessels)
Vertigo positional
Vestibular disorder (disorders of the body's balance (vestibular) system in the inner ear)

male:

Renal failure acute (rapid kidney dysfunction)
Cardiac failure congestive
Loss of consciousness
Pneumonia
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Dementia (madness)
General physical health deterioration (weak health status)
Hypertension (high blood pressure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

What are the common drug interactions of Lortab and Mupirocin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Death

10-19:

n/a

20-29:

Abdominal pain upper
Anaemia (lack of blood)
Anxiety
Asthenia (weakness)
Atrioventricular dissociation (av block)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiomegaly (increased size of heart than normal)
Cellulitis (infection under the skin)

30-39:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Glaucoma (increased fluid pressure in the eye with vision loss)
Neuropathy peripheral (surface nerve damage)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Purpura senile (skin condition in which areas of the skin develop a purplish or reddish-brown appearance due to bleeding of small blood vessels underneath)
Renal failure (kidney dysfunction)

40-49:

Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Bone pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug resistance (reduction in effectiveness of a drug)

50-59:

Blood pressure decreased
Chest discomfort
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)
Respiratory rate increased (excess breathing rate/min)

60+:

Renal failure acute (rapid kidney dysfunction)
Cardiac failure congestive
Hypotension (abnormally low blood pressure)
Loss of consciousness
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Dementia (madness)
General physical health deterioration (weak health status)

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 31.11%
Muscle Spasms (muscle contraction): 11 people, 24.44%
High Blood Cholesterol: 7 people, 15.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.11%
Multiple Allergies (allergy to multiple agents): 4 people, 8.89%
Infection: 4 people, 8.89%
Hypersensitivity: 4 people, 8.89%
Gout (uric acid crystals building up in the body): 4 people, 8.89%
Stress And Anxiety: 3 people, 6.67%
Nausea (feeling of having an urge to vomit): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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