Lortab and Mysoline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Mysoline (primidone). Common drug interactions include cerebrovascular accident among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Mysoline. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Mysoline?

Mysoline has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 2,849 Mysoline users. Check the latest studies of Mysoline.

On Jul, 06, 2026

30 people who take Lortab and Mysoline together, and have interactions are studied.

What are the common drug interactions of Lortab and Mysoline, by gender? *:

female:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug hypersensitivity
Dysgraphia (impaired ability to learn to write)
Fall
Anaemia (lack of blood)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood in stool
Constipation
Contusion (a type of hematoma of tissue in which capillaries)

male:

Acute respiratory failure
Anaemia (lack of blood)
Adverse event
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atelectasis (partial or complete collapse of the lung)
Bone density decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac valve disease (heart valve disease)

What are the common drug interactions of Lortab and Mysoline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Influenza like illness
Sinus congestion (blockage of sinus)
Sinusitis (inflammation of sinus)

40-49:

n/a

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Emotional distress
Kidney infection
Nephropathy (damage to or disease of a kidney)
Tooth loss

60+:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug hypersensitivity
Sepsis (a severe blood infection that can lead to organ failure and death)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atelectasis (partial or complete collapse of the lung)
Blood in stool
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac valve disease (heart valve disease)
Cellulitis (infection under the skin)
Cholecystitis (infection of gallbladder)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 20.00%
Sleep Disorder: 4 people, 13.33%
Muscle Twitching: 4 people, 13.33%
Constipation: 4 people, 13.33%
Abdominal Pain: 4 people, 13.33%
Osteoporosis (bones weak and more likely to break): 2 people, 6.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 6.67%
Essential Tremor: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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