Lortab and Rezulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lortab (acetaminophen; hydrocodone bitartrate) and Rezulin (troglitazone). Common drug interactions include depressed level of consciousness among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Lortab and Rezulin. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

What is Rezulin?

Rezulin has active ingredients of troglitazone. eHealthMe is studying from 8,764 Rezulin users. Check the latest studies of Rezulin.

On Aug, 05, 2026

25 people who take Lortab and Rezulin together, and have interactions are studied.

What are the common drug interactions of Lortab and Rezulin, by gender? *:

female:

Depressed level of consciousness
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Hepatitis (inflammation of the liver)
Hepatitis a antibody positive
Injury
Nausea (feeling of having an urge to vomit)
Pallor
Upper respiratory tract infection
Vaginal haemorrhage (vaginal bleeding)

male:

Cardiac failure congestive
Blood alkaline phosphatase nos increased
Acute myocardial infarction (acute heart attack)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anxiety
Arrhythmia (irregular heartbeat)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Atrioventricular block (heart block)
Bladder disorder

What are the common drug interactions of Lortab and Rezulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Aggression
Blood cholesterol increased
Bradyarrhythmia (heart slowness)
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac flutter (abnormal heart rhythm)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest tightness
Coma (state of unconsciousness lasting more than six hours)

30-39:

Anion gap increased
Asthma
Blood bicarbonate decreased
Blood creatinine increased
Diabetes mellitus inadequate control
Glycosylated haemoglobin increased
Headache (pain in head)
Lactic acidosis (low ph in body tissues)
Proteinuria present
Sepsis (a severe blood infection that can lead to organ failure and death)

40-49:

Liver fatty (fat deposition of liver)
Oedema (fluid collection in tissue)
Rectal bleeding (bleeding from rectum)
Abdominal pain upper
Accident
Blood alkaline phosphatase nos increased
Blood bilirubin increased
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

50-59:

Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cachexia (loss of weight)
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Clamminess (moist, sticky, and cold to the touch)
Collapse (sudden functional breakdown)
Confusion

60+:

Cardiac failure congestive
Abdominal pain
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)

What are the existing conditions these people have? *

Type 1 Diabetes: 3 people, 12.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.00%
Otitis Media (inflammation of the middle ear): 2 people, 8.00%
Insomnia (sleeplessness): 2 people, 8.00%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 8.00%
Back Pain: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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