Losartan and Cefotaxime drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Losartan (losartan potassium) and Cefotaxime (cefotaxime sodium). Common drug interactions include toxic epidermal necrolysis among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Losartan and Cefotaxime. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Losartan?

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 177,692 Losartan users. Check the latest studies of Losartan.

What is Cefotaxime?

Cefotaxime has active ingredients of cefotaxime sodium. eHealthMe is studying from 7,559 Cefotaxime users. Check the latest studies of Cefotaxime.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

39 people who take Losartan and Cefotaxime together, and have interactions are studied.

Losartan and Cefotaxime drug interactions.

What are the common drug interactions of Losartan and Cefotaxime, by gender? *:

female:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Liver disorder (liver diseases)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Face oedema (swelling of face)
Glomerular filtration rate decreased
Renal failure acute (rapid kidney dysfunction)
Acute respiratory distress syndrome
Alopecia (absence of hair from areas of the body)

male:

Pneumonia
Hyperglycaemia (high blood sugar)
Atelectasis (partial or complete collapse of the lung)
Bacterial test positive
Blood pressure decreased
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Coagulopathy (blood's ability to clot is impaired)
Cold sweat

What are the common drug interactions of Losartan and Cefotaxime, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acute respiratory distress syndrome
Back pain
Glomerular filtration rate decreased
Glomerular filtration rate increased
Memory impairment
Multiple allergies (allergy to multiple agents)
Myalgia (muscle pain)
Pneumonia
Respiratory disorder (respiratory disease)
Spinal pain (pain in spine)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Acute respiratory failure
Atelectasis (partial or complete collapse of the lung)
Bacterial test positive
Blood pressure decreased
Cardiac arrest
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Cold sweat
Electrocardiogram t wave inversion
Encephalopathy (functioning of the brain is affected by some agent or condition)

60+:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Face oedema (swelling of face)
Fibrin d dimer increased
Renal failure acute (rapid kidney dysfunction)
Troponin increased
Alopecia (absence of hair from areas of the body)
Blood creatinine increased

What are the existing conditions these people have? *

Organising Pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue): 12 people, 30.77%
Type 2 Diabetes: 6 people, 15.38%
Neoplasm Malignant (cancer tumour): 6 people, 15.38%
Leukocytosis (increased white blood cells): 6 people, 15.38%
Cough: 6 people, 15.38%
Neuropathy Peripheral (surface nerve damage): 3 people, 7.69%
Diarrhea: 3 people, 7.69%
Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 5.13%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 5.13%
Cardiac Failure: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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