Losartan and Tofranil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Losartan (losartan potassium) and Tofranil (imipramine hydrochloride). Common drug interactions include chronic kidney disease among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Losartan and Tofranil. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Losartan?

Losartan has active ingredients of losartan potassium. It is often used in high blood pressure. eHealthMe is studying from 177,686 Losartan users. Check the latest studies of Losartan.

What is Tofranil?

Tofranil has active ingredients of imipramine hydrochloride. It is often used in depression. eHealthMe is studying from 2,012 Tofranil users. Check the latest studies of Tofranil.

On Jul, 21, 2026

23 people who take Losartan and Tofranil together, and have interactions are studied.

Losartan and Tofranil drug interactions.

What are the common drug interactions of Losartan and Tofranil, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Death
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Crying
Fear
Hyperhidrosis (abnormally increased sweating)
Memory impairment

male:

Weight decreased
Body height decreased
Pain in extremity
Platelet count decreased
Pruritus (severe itching of the skin)
Red blood cell abnormality (abnormal red blood cells)
Renal cyst (kidney cyst)
Renal pain (kidney pain)
Urinary tract infection
Vasculitis (inflammation of a blood vessel or blood vessels)

What are the common drug interactions of Losartan and Tofranil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Body height decreased
Cardiac disorder
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Headache (pain in head)
Impaired healing
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Pain in extremity

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Death
Postoperative abscess
Renal failure (kidney dysfunction)

60+:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Panic attack
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Death
Diarrhoea
Intentional self-injury

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 21.74%
Pain: 4 people, 17.39%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.04%
Thyroid Diseases: 2 people, 8.70%
Renal Disorder (kidney disease): 2 people, 8.70%
Pancreatic Carcinoma (pancreatic cancer): 2 people, 8.70%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.70%
Infection: 2 people, 8.70%
High Blood Cholesterol: 2 people, 8.70%
Diabetes: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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