Lotrel and Nplate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lotrel (amlodipine besylate; benazepril hydrochloride) and Nplate (romiplostim). Common drug interactions include contusion among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Lotrel and Nplate. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

What is Nplate?

Nplate has active ingredients of romiplostim. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,850 Nplate users. Check the latest studies of Nplate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

15 people who take Lotrel and Nplate together, and have interactions are studied.

What are the common drug interactions of Lotrel and Nplate, by gender? *:

female:

Contusion (a type of hematoma of tissue in which capillaries)
Therapeutic response decreased (less preventive response)
Thrombocytosis
Drug ineffective
Bone pain
Fatigue (feeling of tiredness)
Herpes zoster
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash

male:

Drug ineffective
Anaemia (lack of blood)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Weight decreased
Bone marrow disorder
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)
Drug effect decreased
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)

What are the common drug interactions of Lotrel and Nplate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bone pain
Contusion (a type of hematoma of tissue in which capillaries)
Fatigue (feeling of tiredness)
Herpes zoster
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash
Sinus congestion (blockage of sinus)
Therapeutic response decreased (less preventive response)
Thrombocytopenia (decrease of platelets in blood)

40-49:

n/a

50-59:

n/a

60+:

Drug ineffective
Thrombocytosis
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Weight decreased
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 14 people, 93.33%

* Approximation only. Some reports may have incomplete information.

Do you take Lotrel and Nplate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously