Lotrel and Xopenex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lotrel (amlodipine besylate; benazepril hydrochloride) and Xopenex (levalbuterol hydrochloride). Common drug interactions include carcinoma in situ among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Lotrel and Xopenex. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

What is Xopenex?

Xopenex has active ingredients of levalbuterol hydrochloride. It is often used in asthma. eHealthMe is studying from 13,816 Xopenex users. Check the latest studies of Xopenex.

On Aug, 07, 2026

63 people who take Lotrel and Xopenex together, and have interactions are studied.

What are the common drug interactions of Lotrel and Xopenex, by gender? *:

female:

Carcinoma in situ (early form of cancer)
Cellulitis (infection under the skin)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Death
Decreased appetite
Dental caries
Dyspepsia (indigestion)
Dysthymic disorder (mild chronic depression disorder)
Electrolyte imbalance
Femur fracture

male:

Pain
Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Anxiety
Abdominal pain
Acute respiratory failure
Arteriosclerosis (thickening and hardening of arteries)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Lotrel and Xopenex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arteriosclerosis (thickening and hardening of arteries)
Cardiac failure congestive
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Hypertensive heart disease

50-59:

Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood triglycerides increased
Breast mass
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carcinoma in situ (early form of cancer)
Cardiomegaly (increased size of heart than normal)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

60+:

Dyspnoea (difficult or laboured respiration)
Pain
Mitral valve incompetence (inefficient heart valve)
Abdominal pain
Drug ineffective
Malaise (a feeling of general discomfort or uneasiness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pyrexia (fever)
Anxiety
Blood potassium increased

What are the existing conditions these people have? *

High Blood Cholesterol: 8 people, 12.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 12.70%
Pain: 6 people, 9.52%
Immunodeficiency Common Variable: 6 people, 9.52%
Blood Pressure Abnormal: 4 people, 6.35%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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