Lotronex and Hydramine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lotronex (alosetron hydrochloride) and Hydramine (diphenhydramine hydrochloride). Common drug interactions include constipation among females.

The phase IV clinical study analyzes what interactions people have when they take Lotronex and Hydramine. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Lotronex?

Lotronex has active ingredients of alosetron hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 6,841 Lotronex users. Check the latest studies of Lotronex.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

On Jul, 08, 2026

24 people who take Lotronex and Hydramine together, and have interactions are studied.

Lotronex and Hydramine drug interactions.

What are the common drug interactions of Lotronex and Hydramine, by gender? *:

female:

Constipation
Diarrhoea
Depression
Palpitations (feelings or sensations that your heart is pounding or racing)
Abdominal distension
Adverse drug reaction
Back pain
Chest pain
Dyspnoea (difficult or laboured respiration)
Fall

male:

n/a

What are the common drug interactions of Lotronex and Hydramine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Abdominal pain
Alopecia (absence of hair from areas of the body)
Constipation
Depression
Gastric dilatation (a twisted stomach)
Memory impairment
Skin discolouration (change of skin colour)
Visual field defect
Vitreous floaters (spots before the eyes)

30-39:

Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Back pain
Chest pain
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Feeling cold
Headache (pain in head)
Loss of consciousness
Pain

40-49:

Hyperhidrosis (abnormally increased sweating)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Vertigo
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

50-59:

Constipation
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Vomiting
Abdominal distension
Abdominal pain
Asthenia (weakness)
Atonic urinary bladder (large urinary bladders that have become dilated but are not emptying properly)
Chest pain
Colitis (inflammation of colon)
Diarrhoea

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Ligament sprain (ligament stretched)
Muscle spasms (muscle contraction)
Lower limb fracture
Seasonal allergy (allergic condition due to certain season)
Sinusitis (inflammation of sinus)
Dyspnoea (difficult or laboured respiration)
Polymyalgia rheumatica (pain in many muscles)
Constipation
Diarrhoea

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 16.67%
Immunodeficiency Common Variable: 3 people, 12.50%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 8.33%
Migraine (headache): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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