Lubiprostone and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Lubiprostone (lubiprostone) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include kidney infection among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Lubiprostone and Hydrocodone. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Lubiprostone?

Lubiprostone has active ingredients of lubiprostone. eHealthMe is studying from 957 Lubiprostone users. Check the latest studies of Lubiprostone.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 15, 2026

14 people who take Lubiprostone and Hydrocodone together, and have interactions are studied.

Lubiprostone and Hydrocodone drug interactions.

What are the common drug interactions of Lubiprostone and Hydrocodone, by gender? *:

female:

Kidney infection
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Post procedural infection
Respiratory tract infection
Road traffic accident
Syncope (loss of consciousness with an inability to maintain postural tone)
Tenderness (pain or discomfort when an affected area is touched)
Urinary tract infection
Visual impairment

male:

Fall
Upper limb fracture

What are the common drug interactions of Lubiprostone and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Nephrolithiasis (calculi in the kidneys)
Nephropathy (damage to or disease of a kidney)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

Chronic kidney disease

50-59:

n/a

60+:

Arthralgia (joint pain)
Pain
Eye disorder
Fall
Fatigue (feeling of tiredness)
Foot fracture
Hypotension (abnormally low blood pressure)
Kidney infection
Loss of consciousness
Lymphadenopathy (disease or enlargement of lymph nodes)

What are the existing conditions these people have? *

Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 7 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 28.57%
Diabetes: 4 people, 28.57%
Pain: 4 people, 28.57%
High Blood Pressure: 3 people, 21.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 21.43%
Headache (pain in head): 3 people, 21.43%
Laxative Supportive Care: 3 people, 21.43%
Migraine (headache): 3 people, 21.43%
Depression: 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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