Luvox and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Luvox (fluvoxamine maleate) and Savella (milnacipran hydrochloride). Common drug interactions include hypertension among females.

The phase IV clinical study analyzes what interactions people have when they take Luvox and Savella. It is created by eHealthMe based on reports of 7 people who take the same drugs from the FDA, and is updated regularly.

What is Luvox?

Luvox has active ingredients of fluvoxamine maleate. It is often used in obsessive-compulsive disorder. eHealthMe is studying from 13,439 Luvox users. Check the latest studies of Luvox.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.



On May, 01, 2026

7 people who take Luvox and Savella together, and have interactions are studied.

Luvox and Savella drug interactions.

What are the common drug interactions of Luvox and Savella, by gender? *:

female:

  1. Hypertension (high blood pressure)
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Kidney infection
  4. Migraine (headache)
  5. Nausea (feeling of having an urge to vomit)
  6. Oral discomfort (pain or irritation in mouth)
  7. Pain in extremity
  8. Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
  9. Renal failure (kidney dysfunction)
  10. Renal injury (kidney injury)

male:

n/a

What are the common drug interactions of Luvox and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Aphthous ulcer (mouth ulcer)
  2. Bone pain
  3. Headache (pain in head)
  4. Kidney infection
  5. Migraine (headache)
  6. Nausea (feeling of having an urge to vomit)
  7. Oral discomfort (pain or irritation in mouth)
  8. Pain in extremity
  9. Angioedema (rapid swelling of the dermis)

30-39:

n/a

40-49:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Renal injury (kidney injury)

50-59:

  1. Hypertension (high blood pressure)
  2. Arthralgia (joint pain)
  3. Gastric bypass
  4. Hypotension (abnormally low blood pressure)
  5. Thyroidectomy

60+:

  1. Somnolence (a state of near-sleep, a strong desire for sleep)

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Luvox and Savella:

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Browse all side effects of Luvox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Savella:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Luvox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Savella and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on fluvoxamine maleate and milnacipran hydrochloride (the active ingredients of Luvox and Savella, respectively), and Luvox and Savella (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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