Macitentan and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macitentan (macitentan) and Ibu (ibuprofen). Common drug interactions include swelling among females and chills among males.

The phase IV clinical study analyzes what interactions people have when they take Macitentan and Ibu. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Macitentan?

Macitentan has active ingredients of macitentan. eHealthMe is studying from 7,371 Macitentan users. Check the latest studies of Macitentan.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,529 Ibu users. Check the latest studies of Ibu.

On Apr, 22, 2026

33 people who take Macitentan and Ibu together, and have interactions are studied.

What are the common drug interactions of Macitentan and Ibu, by gender? *:

female:

Swelling
Drug ineffective
Acidosis (build-up of carbon dioxide in the blood)
Bronchopulmonary dysplasia (chronic lung disorder in infants - enlargement of an organ or tissue by the proliferation of cells of an abnormal type)
Dysphagia (a condition in which swallowing is difficult or painful)
Heart valve incompetence (heart's valves do not work correctly)
Lethargy (tiredness)
Pallor
Pulmonary hypertensive crisis (increase in blood pressure in the lung artery-crisis)
Respiratory failure (inadequate gas exchange by the respiratory system)

male:

Chills (felling of cold)
Diarrhoea
Small intestinal obstruction (blockage in small intestine)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Vomiting
Disease progression
Dizziness
Dyspnoea (difficult or laboured respiration)
Fall
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Macitentan and Ibu, by age (0-1 to 60+)? *:

0-1:

Upper respiratory tract infection
Acidosis (build-up of carbon dioxide in the blood)
Bronchopulmonary dysplasia (chronic lung disorder in infants - enlargement of an organ or tissue by the proliferation of cells of an abnormal type)
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Heart valve incompetence (heart's valves do not work correctly)
Lethargy (tiredness)
Pallor
Pulmonary hypertensive crisis (increase in blood pressure in the lung artery-crisis)
Respiratory failure (inadequate gas exchange by the respiratory system)

2-9:

n/a

10-19:

Gingival pain (gum pain)
Haemorrhage (bleeding)
Swelling

20-29:

Hypotension (abnormally low blood pressure)
Syncope (loss of consciousness with an inability to maintain postural tone)

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Bilirubin conjugated increased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood bilirubin increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Epistaxis (bleed from the nose)
Gamma-glutamyltransferase increased

40-49:

Subdural haematoma (blood collects between the skull and the surface of the brain)

50-59:

Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Dyspepsia (indigestion)
Hospitalisation
Oxygen consumption increased
Pulmonary veno-occlusive disease (obstructive disease of the pulmonary veins)
Dyspnoea (difficult or laboured respiration)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac disorder
Decreased appetite

60+:

Fall
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Blood glucose decreased
Bradycardia (abnormally slow heart action)
Cardiac failure
Haemoglobin decreased
Iron deficiency anaemia
Abdominal pain
Adverse drug reaction
Adverse event

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 17 people, 51.52%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 15 people, 45.45%
Headache (pain in head): 5 people, 15.15%
High Blood Pressure: 3 people, 9.09%
Diarrhea: 3 people, 9.09%
Respiratory Tract Infection: 2 people, 6.06%
Depression: 2 people, 6.06%
Dyspnea (difficult or laboured breathing): 2 people, 6.06%
High Blood Cholesterol: 2 people, 6.06%
Hypokalemia (low potassium): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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