Macrobid and Hc drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Hc (hydrocortisone). Common drug interactions include chronic left ventricular failure among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Hc. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Hc?

Hc has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 1,369 Hc users. Check the latest studies of Hc.

On Apr, 12, 2026

12 people who take Macrobid and Hc together, and have interactions are studied.

What are the common drug interactions of Macrobid and Hc, by gender? *:

female:

Chronic left ventricular failure (long lasting functional impairment of left ventricle of heart)
Dry eye (lack of adequate tears)
Dysuria (painful or difficult urination)
Renal disorder (kidney disease)
Asthenia (weakness)
Back pain
Chills (felling of cold)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dizziness
Fatigue (feeling of tiredness)

male:

Back pain
Colitis ulcerative (inflammation of colon with ulcer)
Viral infection
Depression
Inflammatory bowel disease
Injury
Intestinal haemorrhage (bleeding from intestine)
Intestinal obstruction
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

What are the common drug interactions of Macrobid and Hc, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Injury
Medical device pain (pain due to medical device)
Post procedural discomfort
Procedural pain
Uterine perforation (accidental puncture of the uterus)

30-39:

n/a

40-49:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Abdominal pain
Cholecystitis chronic (long lasting infection of gallbladder)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Erythema (redness of the skin)
Hypersensitivity
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pruritus (severe itching of the skin)
Rash

50-59:

Back pain
Chills (felling of cold)
Dizziness
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Feeling hot
Hot flush (sudden feelings of heat)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

60+:

Thrombocytopenia (decrease of platelets in blood)
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Hyperhidrosis (abnormally increased sweating)
Inflammatory bowel disease
Injury
Intestinal haemorrhage (bleeding from intestine)
Intestinal obstruction
Loss of consciousness

What are the existing conditions these people have? *

Pain: 5 people, 41.67%
Birth Control: 3 people, 25.00%
Intertrigo (inflammation (rash) of the body folds (adjacent areas of skin)): 2 people, 16.67%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 2 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 16.67%
Migraine (headache): 2 people, 16.67%
Joint Pain: 2 people, 16.67%
Sleep Disorder: 2 people, 16.67%
Hormone Level Abnormal: 2 people, 16.67%
Hot Flush (sudden feelings of heat): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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