Macrobid and Lysine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Lysine (lysine). Common drug interactions include alopecia among females.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Lysine. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Lysine?

Lysine has active ingredients of lysine. It is often used in herpes labialis (oral herpes simplex). eHealthMe is studying from 16,525 Lysine users. Check the latest studies of Lysine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

31 people who take Macrobid and Lysine together, and have interactions are studied.

What are the common drug interactions of Macrobid and Lysine, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Depression
Dermatitis diaper (diaper rash is a common form of inflamed skin)
Dizziness
Fatigue (feeling of tiredness)
Feeding disorder (when children refuse to eat certain food groups)
Feeling hot
Gastrointestinal infection (infection of stomach and intestine)
Hemiparesis (weakness on one side of the body)
Hypersensitivity

male:

n/a

What are the common drug interactions of Macrobid and Lysine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Activities of daily living impaired
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Fear
Injury
Pain
Painful respiration
Pulmonary embolism (blockage of the main artery of the lung)
Sleep disorder due to a general medical condition

30-39:

n/a

40-49:

Allergy to animal

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Depression
Diarrhoea
Headache (pain in head)
Infusion related reaction
Injection site nerve damage
Poor venous access
Retching (strong involuntary effort to vomit)
Stress
Vertigo

60+:

Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Dizziness
Fatigue (feeling of tiredness)
Feeding disorder (when children refuse to eat certain food groups)
Feeling hot
Gastrointestinal infection (infection of stomach and intestine)
Hemiparesis (weakness on one side of the body)
Hypersensitivity
Joint stiffness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 22.58%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 19.35%
High Blood Cholesterol: 5 people, 16.13%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 16.13%
Gait Disturbance: 4 people, 12.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 12.90%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 12.90%
Type 2 Diabetes: 3 people, 9.68%
Diarrhea: 3 people, 9.68%
High Blood Pressure: 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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