Macrobid and Magnesium oxide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Magnesium oxide (magnesium). Common drug interactions include chest pain among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Magnesium oxide. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Magnesium oxide?

Magnesium oxide has active ingredients of magnesium. It is often used in migraine. eHealthMe is studying from 19,022 Magnesium oxide users. Check the latest studies of Magnesium oxide.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

44 people who take Macrobid and Magnesium oxide together, and have interactions are studied.

Macrobid and Magnesium oxide drug interactions.

What are the common drug interactions of Macrobid and Magnesium Oxide, by gender? *:

female:

Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)
Death
Dysphagia (a condition in which swallowing is difficult or painful)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Local swelling (swelling at the site of some application of substance or injury)
Memory impairment
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)

male:

Asthenia (weakness)
Chest pain
Red blood cell count decreased
White blood cell count decreased
Anal abscess
Cellulitis (infection under the skin)
Fall
Genital abscess (build up of pus in genital)
Head injury
Injection site bruising

What are the common drug interactions of Macrobid and Magnesium Oxide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Actinomyces test positive
Acute psychosis (period of mentally unstable behaviour)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Bone disorder
Breath odour
Candidiasis (candidiasis or thrush is a fungal infection)
Cellulitis (infection under the skin)

30-39:

Anaemia (lack of blood)
Anal abscess
Cellulitis (infection under the skin)
Chronic kidney disease
Complications of transplanted kidney
Confusional state
Dyspnoea (difficult or laboured respiration)
Genital abscess (build up of pus in genital)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nephrogenic anaemia (anaemia due to kidney disease)

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

50-59:

Central obesity (belly fat)
Drug hypersensitivity
Dysuria (painful or difficult urination)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Ill-defined disorder
Insomnia (sleeplessness)
Intestinal obstruction
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Proteinuria (presence of protein in the urine)

60+:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Full blood count decreased
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Red blood cell count decreased
Thrombocytopenia (decrease of platelets in blood)
Vomiting
White blood cell count decreased
Cellulitis (infection under the skin)

What are the existing conditions these people have? *

Dyspnea (difficult or laboured breathing): 9 people, 20.45%
Fever: 9 people, 20.45%
Pain: 9 people, 20.45%
Oedema (fluid collection in tissue): 9 people, 20.45%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 8 people, 18.18%
Renal Cell Carcinoma (a kidney cancer): 8 people, 18.18%
Psychotic Disorder: 8 people, 18.18%
Pneumonia: 8 people, 18.18%
Respiratory Tract Infection: 8 people, 18.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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