Macrobid and Micronor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Micronor (norethindrone). Common drug interactions include cholelithiasis among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Micronor. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Micronor?

Micronor has active ingredients of norethindrone. It is often used in birth control. eHealthMe is studying from 1,344 Micronor users. Check the latest studies of Micronor.

On Jul, 15, 2026

11 people who take Macrobid and Micronor together, and have interactions are studied.

Macrobid and Micronor drug interactions.

What are the common drug interactions of Macrobid and Micronor, by gender? *:

female:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Injury
Nephrolithiasis (calculi in the kidneys)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bile duct stone
Culture urine positive
Emotional distress
Gallbladder disorder
General physical health deterioration (weak health status)

male:

Abdominal distension
Acute respiratory distress syndrome
Complications of maternal exposure to therapeutic drugs
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug exposure during pregnancy
Gastroenteritis (inflammation of stomach and intestine)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemorrhage (bleeding)
Hepatic failure (liver failure)
Hydrocele

What are the common drug interactions of Macrobid and Micronor, by age (0-1 to 60+)? *:

0-1:

Abdominal distension
Acute respiratory distress syndrome
Back pain
Bradycardia (abnormally slow heart action)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Clostridium colitis (inflammation of colon by clostridium difficile bacteria infection)
Complications of maternal exposure to therapeutic drugs
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug exposure during pregnancy
Gastroenteritis (inflammation of stomach and intestine)

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Bile duct stone
Culture urine positive
Emotional distress
Gallbladder disorder
General physical health deterioration (weak health status)
Pain
Abdominal pain
Alanine aminotransferase increased
Aspartate aminotransferase increased

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Agitation (state of anxiety or nervous excitement)
Bipolar disorder (mood disorder)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Nephrolithiasis (calculi in the kidneys)
Psychotic disorder

What are the existing conditions these people have? *

Arrhythmias (irregular heartbeat): 4 people, 36.36%
Stress And Anxiety: 1 person, 9.09%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 9.09%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 1 person, 9.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 9.09%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 1 person, 9.09%
Fungal Infection: 1 person, 9.09%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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