Macrobid and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Modafinil (modafinil). Common drug interactions include multiple sclerosis relapse among females.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Modafinil. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 28, 2026

53 people who take Macrobid and Modafinil together, and have interactions are studied.

Macrobid and Modafinil drug interactions.

What are the common drug interactions of Macrobid and Modafinil, by gender? *:

female:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Fatigue (feeling of tiredness)
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Bladder dysfunction
Blood pressure immeasurable
Chills (felling of cold)
Dermatitis diaper (diaper rash is a common form of inflamed skin)

male:

n/a

What are the common drug interactions of Macrobid and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Headache (pain in head)
Vomiting

40-49:

Injection site atrophy (injection site wasting or decreasing in size of a body organ, tissue, or part)
Lacrimation increased
Lung infection
Maternal exposure before pregnancy (use of substance before pregnancy)
Mean cell haemoglobin concentration increased (more concentration of haemoglobin in a given volume of packed red blood cells)
Mean platelet volume increased (more than normal average size of platelet cells in blood)
Oral herpes (viral infection of mouth)
Peroneal nerve palsy
Productive cough
Pyrexia (fever)

50-59:

Depression
Dizziness
Fall
Kidney infection
Lower limb fracture
Memory impairment
Nephrolithiasis (calculi in the kidneys)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Neuropathy peripheral (surface nerve damage)
Postoperative wound complication

60+:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Alopecia (absence of hair from areas of the body)
Dermatitis diaper (diaper rash is a common form of inflamed skin)
Dizziness
Fatigue (feeling of tiredness)
Feeding disorder (when children refuse to eat certain food groups)
Feeling hot
Gastrointestinal infection (infection of stomach and intestine)
Hemiparesis (weakness on one side of the body)
Hypersensitivity

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 20 people, 37.74%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 16.98%
Gait Disturbance: 7 people, 13.21%
Pain: 5 people, 9.43%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 7.55%
Stress And Anxiety: 3 people, 5.66%
Migraine (headache): 3 people, 5.66%
Hypersensitivity: 3 people, 5.66%
Fatigue (feeling of tiredness): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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