Macrobid and Soma drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Soma (carisoprodol). Common drug interactions include hypoaesthesia among females and akathisia among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Soma. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Soma?

Soma has active ingredients of carisoprodol. It is often used in muscle spasms. eHealthMe is studying from 17,137 Soma users. Check the latest studies of Soma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

61 people who take Macrobid and Soma together, and have interactions are studied.

What are the common drug interactions of Macrobid and Soma, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)
Impaired healing
Loss of consciousness
Mood swings (an extreme or rapid change in mood)
Morganella infection (infection by morganella morganii bacteria)
Muscular weakness (muscle weakness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Osteomyelitis (infection of bone)

male:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Drug diversion
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysaesthesia (abnormal sensation)
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)

What are the common drug interactions of Macrobid and Soma, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Abdominal tenderness
Arthralgia (joint pain)
Diarrhoea
Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Haemoperitoneum (presence of blood in the peritoneal cavity)
Hypotension (abnormally low blood pressure)
Menstruation irregular
Nausea (feeling of having an urge to vomit)
Ovarian cyst (fluid filled sac of the ovary)

20-29:

Anxiety
Emotional distress
Injury
Depressed mood
Depression
Activities of daily living impaired
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Device dislocation
Fallopian tube cyst (sac of fallopian tube filled with air /fluid)
Fear

30-39:

Acute respiratory failure
Delirium (wild excitement)
Dizziness
Influenza like illness
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Septic shock (shock due to blood infection)

40-49:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder disorder
Headache (pain in head)
Migraine (headache)
Pain in extremity
Abdominal pain
Balance disorder
Blood glucose increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

50-59:

Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Insomnia (sleeplessness)
Intervertebral disc degeneration (spinal disc degeneration)
Joint injury
Lumbar vertebral fracture
Malaise (a feeling of general discomfort or uneasiness)
Osteoporosis (bones weak and more likely to break)
Palpitations (feelings or sensations that your heart is pounding or racing)
Rhinitis allergic (inflammation of the nasal airways due to allergy)

60+:

Headache (pain in head)
Drug ineffective
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Memory impairment
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anxiety
Balance disorder

What are the existing conditions these people have? *

Pain: 10 people, 16.39%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 14.75%
High Blood Pressure: 7 people, 11.48%
Neuropathy Peripheral (surface nerve damage): 7 people, 11.48%
Depression: 7 people, 11.48%
High Blood Cholesterol: 6 people, 9.84%
Cataract (clouding of the lens inside the eye): 6 people, 9.84%
Diabetes: 6 people, 9.84%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 6 people, 9.84%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 6 people, 9.84%

* Approximation only. Some reports may have incomplete information.

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