Macrobid and Tamiflu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Tamiflu (oseltamivir phosphate). Common drug interactions include fall among females and scar among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Tamiflu. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Tamiflu?

Tamiflu has active ingredients of oseltamivir phosphate. It is often used in the flu. eHealthMe is studying from 22,209 Tamiflu users. Check the latest studies of Tamiflu.

On Jul, 06, 2026

53 people who take Macrobid and Tamiflu together, and have interactions are studied.

What are the common drug interactions of Macrobid and Tamiflu, by gender? *:

female:

Fall
Hypertension (high blood pressure)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aortic arteriosclerosis (hardening of the aortic arteries)
Cough
Discomfort
Dry mouth
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Feeling jittery

male:

Scar
Acute sinusitis
Bone loss
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Candidiasis (candidiasis or thrush is a fungal infection)
Carcinoma in situ of skin
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Constipation

What are the common drug interactions of Macrobid and Tamiflu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Scar
Acute sinusitis
Anaemia (lack of blood)
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthropathy
Back pain
Bone disorder

10-19:

Gallbladder operation
Hospitalisation

20-29:

Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Diarrhoea
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Helicobacter gastritis (inflammation of the inner lining of the stomach caused by helicobacter pylori (h. pylori) a bacterium)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Nausea (feeling of having an urge to vomit)
Peptic ulcer

30-39:

Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Coma (state of unconsciousness lasting more than six hours)
Ear pain
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hallucination (an experience involving the perception of something not present)
Hepatic failure (liver failure)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)

40-49:

Drug ineffective
H1n1 influenza (flu (influenza), which is caused by virus influenza a (h1n1))
Injection site erythema (redness at injection site)
Weight decreased
Abdominal discomfort
Anal fistula

50-59:

Alcohol abuse
Loss of consciousness
Self esteem decreased (self worth reduced)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Suicidal ideation
Weight increased

60+:

Pain
Malaise (a feeling of general discomfort or uneasiness)
Discomfort
Dry mouth
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Feeling jittery
Fractured sacrum
Gingival bleeding (bleeding gums)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 24 people, 45.28%
Pain: 6 people, 11.32%
Immunodeficiency Common Variable: 6 people, 11.32%
Depression: 4 people, 7.55%
Stress And Anxiety: 3 people, 5.66%
High Blood Cholesterol: 3 people, 5.66%
Cardiac Disorder: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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