Macrobid and Velcade drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline) and Velcade (bortezomib). Common drug interactions include osteomyelitis among females and pancytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Macrobid and Velcade. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Velcade?

Velcade has active ingredients of bortezomib. It is often used in multiple myeloma. eHealthMe is studying from 66,422 Velcade users. Check the latest studies of Velcade.

On Jul, 05, 2026

40 people who take Macrobid and Velcade together, and have interactions are studied.

What are the common drug interactions of Macrobid and Velcade, by gender? *:

female:

Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Pain in extremity
Spinal osteoarthritis (joint cartilage loss in spine)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonia
Asthenia (weakness)
Facial pain

male:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary retention (the inability to completely or partially empty the bladder)

What are the common drug interactions of Macrobid and Velcade, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abscess (pus)
Anaemia of chronic disease
Anxiety
Arrhythmia supraventricular (irregular heartbeat supraventricular origin)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Back pain
Blood creatinine increased
Blood glucose increased
Blood pressure fluctuation

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Weight decreased
Abdominal discomfort
Chronic kidney disease
Decreased appetite
Dry skin
Renal failure (kidney dysfunction)

60+:

Anxiety
Back pain
Diarrhoea
Spinal osteoarthritis (joint cartilage loss in spine)
Facial pain
Asthenia (weakness)
Anaemia (lack of blood)
Arthralgia (joint pain)
Bone marrow failure
Cystitis noninfective (non-infectious inflammation of the wall of the bladder)

What are the existing conditions these people have? *

Pain: 8 people, 20.00%
Muscle Spasms (muscle contraction): 6 people, 15.00%
Nausea (feeling of having an urge to vomit): 4 people, 10.00%
Nausea And Vomiting: 3 people, 7.50%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 2 people, 5.00%
Quit Smoking: 2 people, 5.00%
Pleural Effusion (water on the lungs): 2 people, 5.00%
Oedema (fluid collection in tissue): 2 people, 5.00%
Multiple Allergies (allergy to multiple agents): 2 people, 5.00%
Indigestion: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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